Coagulation final
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| Which ratio of anticoagulant to blood is acceptable for coagulation procedures | 9:1
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| Platelet aggregation is dependent on the presence of | EPI (epinephrine, collagen, and calcium)
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| The vasoconstrictor substance released from the platelets at the site of injury is | thromboxane A2
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| Which organ is responsible for sheltering 20% of the platelet volume in the circulation? | spleen
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| The main substrate of the coagulation system is | fibrinogen
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| A decreased platelet count is most often anticipated when a patient demonstrates | bleeding mucous membranes, gingival bleeding, existaxis purpura, and petechiae
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| which of the following is a component of the fibrinolytic system | plasminogen, plasminogen activators, plasmin, fibrin, fibrin degradation products and inhibotors of plasminogen and plasmin, urokinase
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| which of the following is NOT a component of the fibrinolytic system | thrombin
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| The prothrombin group consists of factors | II, VII, IX, X
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| Anticoagulant, monitored by activated partial thrombin time (aPTT) or anti-factor Xa assay and inactivates thrombin | Heparin
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| Which factor is involved in contact activation | fitzgerald factor also known as High-Molecular-weight-kininogen (HMWK)
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| Which factor is measured by both PT and aPTT | factor I, II, V, X
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| Which protein is not made in the liver | Von Willebrand
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| In the prothrombin test, the patient's citrated plasma is combined with | thromboplastin and CaCl (calcium chloride)
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| Which of the following causes irreversible inactivation of platelets | asprin
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| The autoantibody generated in ITP (idiopatic thrombotic purpura) is directed against | sites on a glycoprotein GPIIb-IIIa or GPIb-IX
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| Which of the following are platelet adhesion disorders | VonWillebrands(vWD), Benard-Soulier, Glanzman's Thrombasthenia
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| Decompression acetate (DDAVP) is an effective treatment for vWD because | the release of endothelial vWF and may be given and injectable agent or nasal spray, portable and convenient
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| In thrombotic thrombocytopenia purpura, which of the following statements are most accurate | deficiency of ADAMTS-13, a large metalloprotease responsible for cleaving large von willebrand factor into small proteins
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| The presence of thrombocytopenia and giant platelets in a patient's plasma is characteristic of | Bernard-Soulier Syndrome
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| Which of the following conditions may result in thrombocytosis | Primarily seen in Myeloproliferative disorders (Platelets are increased with impaired function
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| In hemolyic uremic syndrome(HUS), which of the following statements is the most accurate | the toxin responsible Eschericha Coli 0157:H7 or shiga; mimics TTP
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| Platelet aggregation cannot occur if ______ is absent | GPIIb/IIIa, fibrinogen, or calcium
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| The anticoagulant of choice for routine coagulation procedure is | sodium citrate
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| The process of fibrin degradation is called ____ and is controlled by the enzyme _____. | Fibrinolysis, plasmin
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| A prolonged thrombin and a normal repilase time is indicative of | heparin therapy
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| All of the following are functions of thrombin except | activating thromboplasmin
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| D-dimers may be elevated in which of the following | Deep vein thrombosis (DVT)
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| A primary inhibitor of the fibrinolytic system is | alpha-2 antiplasmin
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| Normal results of a thrombin time is | 10-15 sec
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| Which are the byproducts of fibrinolysis | FDPs (Fibrin degradation products) and D-dimers
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| Which of the following hematology disorders will likely trigger an episode of DIC | APL, AML, microangiopathic orders, thrombotic thrombocytopenia Purpura (TTP)
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| The D-dimer test measures | breakdown of fibrin
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| Obstetrical complications like retained placenta or abruption placenta are a leading cause of | DIC (desseminated Intravascular Coagulation)
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| The international normalized ratio (INR) is useful in | Warfin (coumadin) monitoring
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| All of the following statements are true of coumadin | inhibits vitamin K; vitamin K dependent factors II, VII, IX, X; 36 hr half-life
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| The lupus anticoagulant is directed against | phospholipid binding proteins
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| Heparin induced thrombocytopenia (HIT) usually occurs | 5-14 days after heparin therapy
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| Factor 8 inhibitors | Thrombin - platelet phospholipid, develops in 15-20% of all individuals with hemophilia, autoantibodies against factor VIII - TIME AND TEMP DEPENDENT,capable of neutralizing the coagulant portion of factor VIII
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| What therapy may be used for a hemophiliac who is bleeding but has a low titter factor VIII inhibitor | high dose of factor 8 consintrait
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| Which of the following is the most prevalent inherited bleeding disorder | von Willebrand
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| A prolonged aPTT is corrected with factor VIII-deficient plasma but not with factor IX deficient plasma. What factor is deficient? | IX
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| Factor assays measure percent activity of a given factor mixing the patients plasma with | factor deficient plasma
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| Which platelet responses are most likely associated with hemophilla A | platelets work fine, decrease clotting factors VIII and IX
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| Long term antibiotic therapy is a cause for bleeding because it disrupts | disrupts intestinal flora which disrupts vitamin K synthysis
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| Which of the following is the most useful in differentiation hemophillia A and Hemophillia B | factor assays VIII (A) and IX (B)
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| The treatment of choice for hemophillia A individual is | recombinant factor products - factor VIII consintrait
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