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Coagulation final

QuestionAnswer
Which ratio of anticoagulant to blood is acceptable for coagulation procedures 9:1
Platelet aggregation is dependent on the presence of EPI (epinephrine, collagen, and calcium)
The vasoconstrictor substance released from the platelets at the site of injury is thromboxane A2
Which organ is responsible for sheltering 20% of the platelet volume in the circulation? spleen
The main substrate of the coagulation system is fibrinogen
A decreased platelet count is most often anticipated when a patient demonstrates bleeding mucous membranes, gingival bleeding, existaxis purpura, and petechiae
which of the following is a component of the fibrinolytic system plasminogen, plasminogen activators, plasmin, fibrin, fibrin degradation products and inhibotors of plasminogen and plasmin, urokinase
which of the following is NOT a component of the fibrinolytic system thrombin
The prothrombin group consists of factors II, VII, IX, X
Anticoagulant, monitored by activated partial thrombin time (aPTT) or anti-factor Xa assay and inactivates thrombin Heparin
Which factor is involved in contact activation fitzgerald factor also known as High-Molecular-weight-kininogen (HMWK)
Which factor is measured by both PT and aPTT factor I, II, V, X
Which protein is not made in the liver Factor VIII (antihemophilic)
In the prothrombin test, the patient's citrated plasma is combined with thromboplastin and CaCl (calcium chloride)
Which of the following causes irreversible inactivation of platelets asprin
The autoantibody generated in ITP (idiopatic thrombotic purpura) is directed against sites on a glycoprotein GPIIb-IIIa or GPIb-IX
Which of the following are platelet adhesion disorders VonWillebrands(vWD), Benard-Soulier, Glanzman's Thrombasthenia
Decompression acetate (DDAVP) is an effective treatment for vWD because the release of endothelial vWF and may be given and injectable agent or nasal spray, portable and convenient
In thrombotic thrombocytopenia purpura, which of the following statements are most accurate deficiency of ADAMTS-13, a large metalloprotease responsible for cleaving large von willebrand factor into small proteins
The presence of thrombocytopenia and giant platelets in a patient's plasma is characteristic of Bernard-Soulier Syndrome
Which of the following conditions may result in thrombocytosis Primarily seen in Myeloproliferative disorders (Platelets are increased with impaired function
In hemolyic uremic syndrome(HUS), which of the following statements is the most accurate the toxin responsible Eschericha Coli 0157:H7 or shiga; mimics TTP
Platelet aggregation cannot occur if ______ is absent GPIIb/IIIa, fibrinogen, or calcium
The anticoagulant of choice for routine coagulation procedure is sodium citrate
The process of fibrin degradation is called ____ and is controlled by the enzyme _____. Fibrinolysis, plasmin
A prolonged thrombin and a normal repilase time is indicative of heparin therapy
All of the following are functions of thrombin except activating thromboplasmin
D-dimers may be elevated in which of the following Deep vein thrombosis (DVT)
A primary inhibitor of the fibrinolytic system is alpha-2 antiplasmin
Normal results of a thrombin time is 10-15 sec
Which are the byproducts of fibrinolysis FDPs (Fibrin degradation products) and D-dimers
Which of the following hematology disorders will likely trigger an episode of DIC APL, AML, microangiopathic orders, thrombotic thrombocytopenia Purpura (TTP)
The D-dimer test measures breakdown of fibrin
Obstetrical complications like retained placenta or abruption placenta are a leading cause of DIC (desseminated Intravascular Coagulation)
The international normalized ratio (INR) is useful in Warfin (coumadin) monitoring
All of the following statements are true of coumadin inhibits vitamin K; vitamin K dependent factors II, VII, IX, X; 36 hr half-life
The lupus anticoagulant is directed against phospholipid binding proteins
Heparin induced thrombocytopenia (HIT) usually occurs 5-14 days after heparin therapy
Factor 8 inhibitors Thrombin - platelet phospholipid, develops in 15-20% of all individuals with hemophilia, autoantibodies against factor VIII - TIME AND TEMP DEPENDENT,capable of neutralizing the coagulant portion of factor VIII
What therapy may be used for a hemophiliac who is bleeding but has a low titter factor VIII inhibitor high dose of factor 8 consintrait
Which of the following is the most prevalent inherited bleeding disorder von Willebrand
A prolonged aPTT is corrected with factor VIII-deficient plasma but not with factor IX deficient plasma. What factor is deficient? IX
Factor assays measure percent activity of a given factor mixing the patients plasma with factor deficient plasma
Which platelet responses are most likely associated with hemophilla A platelets work fine, decrease clotting factors VIII and IX
Long term antibiotic therapy is a cause for bleeding because it disrupts disrupts intestinal flora which disrupts vitamin K synthysis
Which of the following is the most useful in differentiation hemophillia A and Hemophillia B factor assays VIII (A) and IX (B)
The treatment of choice for hemophillia A individual is recombinant factor products - factor VIII consintrait
Created by: svankirk