Ch 2
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| A synonym for an antigenic determinant is: | Epitope
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| Genetically different individuals of the same species are referred to as : | Allogenic
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| Antigenic substances can be composed of: | Lg polysaccharides, proteins and glycoproteins
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| The most important characteristics of an antigen is: | Foreignness, degradability, molec. Weight
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| An antibody is composed of : | Proteins
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| 19S | IgM
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| What is the highest antibody in the serum or plasma of health person | IgG
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| what antibody can exist as a dimer | IgA
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| What antibody has the shortest life span | IgE
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| Which antibody has no known sub classes | IgD
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| Which antibody increases in infectious diseases, collagen and hematologic disorders? | IgG
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| Which antibody is produced early in an immune response? | IgM
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| Which antibody is the predominant immunoglobulin in secretions? | IgA
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| What is the primary cell membrane immunoglobulin? | IgD
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| Which antibody mediates some types of hypersensitivity reactions? | IgE
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| Dominate type found on all animals in a species | Isotype
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| Found on the immunoglobins of some but not all of a species | allotype
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| individual determinants characteristic of each antibody | idotype
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| what is the sequence of events for a typical immune response | Lag phase, log phase, plateau, decline
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| Which of the following is false in an anamnestic response vs a primary response | IgM is predominate
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| Which type is capable of placental transfer? | IgG
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| ability of an antibody to combine with one antigen vs another | specificity
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| Strength of a bond between a single antigenic determinant and an individual combining site | Affinity
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| Strength with which a multivalent antibody binds to a multivalent antigen | avidity
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| non-covalent combination of an antigen with its respective specific antibody | Immune complex
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| What are the types of bonds involved in antigen-antibody reactions | Hydrophobic, hydrogen, VanDerWaals
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| Monocovalent antibodies have also been referred to as what? | incomplete antibodies
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| Antibody engineered to bind to a single epitope, purified from a single cell, are used to classify and identify specific cellular membrane characteristics | Monoclonal antibody
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| Antigens are characterized by : | usually Lg organic molecules, glycolipids or glycoproteins, also called immunogens
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| Antibodies are also referred to as- | Immunoglobulins
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| Accounts for 10% of the Ig pool, largely confined to the intravascular system | IgM
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| Diffuses more readily into extra vascular spaces, neutralizes toxins, and binds to microorganisms | IgG
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| Found in tears, saliva, colostrum, milk, and intestinal secretions | IgA
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| Mediates some types of hypersensitivity | IgE
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| Makes up less that 1% of the total immunoglobulins | IgD
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| What is the short chain of an Ig Called? | Fab Section
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| What is the long or heavy chain of an Ig Called? | Fc Section
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| In the Immune "bell curve" what are the 4 areas called, how are they different between 1st exposure and the 2nd exposure? | "A Lag phase
B Log Phase
C Plateau
D Decline Phase
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| What are the characteristics of secondary response | IgG is predominant, It has a shorter Lag phase, more gradual decline
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| Bonding of antigen to antibody happens exclusively in | Noncovalent bonding
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| The strongest bonds result from what? | Goodness of fit
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| Monoclonal have what characteristics | cloned from single cell, purified antibody, engineered to bind to a single antigen
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| T or F, IgM is predominate in a secondary response | False
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