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Ch End 3

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Self-renewal and pluripotential differentiation potential are characteristics of:   B. stem cells  
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Precursor cells that are morphologically recognizable are found in the   C. maturing cell compartment  
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The CFU-EMk gives rise to:   D. erythrocytes and megakaryocytes  
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Hematopoietic cells derived from the CFU-GEMM   platelets, eosinophils, erythrocytes ... (NOT lymphocytes!)  
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Cell is most sensitive to erythropoietin:   D. CFU-E  
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Considered “early acting, multilineage” cytokines   GM-CSF, SCF, IL-3  
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a cytokine with multiple biologic activities   Pleiotrophy  
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Cytokine regulation in which the cytokine is not secreted by the producing cell but remains membrane bound, necessitating direct cell-cell contact to achieve the desired effect is:   C. juxtacrine  
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Thought to be negative regulators of hematopoiesis   TGF beta, TNF, MIP-1alpha  
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The hematopoietic microenvironment is composed of:   C. marrow stromal cells and extracellular matrix  
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