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Ch End 3

Self-renewal and pluripotential differentiation potential are characteristics of: B. stem cells
Precursor cells that are morphologically recognizable are found in the C. maturing cell compartment
The CFU-EMk gives rise to: D. erythrocytes and megakaryocytes
Hematopoietic cells derived from the CFU-GEMM platelets, eosinophils, erythrocytes ... (NOT lymphocytes!)
Cell is most sensitive to erythropoietin: D. CFU-E
Considered “early acting, multilineage” cytokines GM-CSF, SCF, IL-3
a cytokine with multiple biologic activities Pleiotrophy
Cytokine regulation in which the cytokine is not secreted by the producing cell but remains membrane bound, necessitating direct cell-cell contact to achieve the desired effect is: C. juxtacrine
Thought to be negative regulators of hematopoiesis TGF beta, TNF, MIP-1alpha
The hematopoietic microenvironment is composed of: C. marrow stromal cells and extracellular matrix
Created by: BOMLT