BB Exam 3
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| HTLA characteristics | -IgG usually non C binder -against high incidence antigens - seen in multiply transfused patients - hides alloantibodies - reacts weakly w/cord cells
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| Chido/Rodgers system | Antigens water soluble; adsorbed onto RBC from plasma--part of C4d on chrome 6-- Ag not well developed at birth--98% white are Cha+
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| Are Ch & Rg antigens destroyed by enzymes? | Yes
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| Is it necessary to give Ch/Rg antigen negative blood?? | No, because the Ab will be neutralized by plasma prior to transfusion
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| Procedures to ID Ch/Rg antigens (4) | 1) Ag neg cells reacted w/plasma 2)enzyme treatment 3)reaction of plasma w/C4d coated RBCs 4)Neutralization w/plasma from Ch/Rg positive person
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| Plasma inhibition (neutralization) for Ch/Rg | -Pooled plasma from 6 pts
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| What is the control of plasma inhibition? | Albumin
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| Sid (Sda) Antigen | 91% of pop has...variable expression...cord cells lack
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| Sda antibody | ALWAYS gives MF reaction (refractile).....Neutralizable with urine from Sda+ person
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| Do you need to give Sda negative units? | No
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| Bg antigens | Class I HLA, strongly expressed on WBCs & PLTs, IgG cline sig, appears as Ab to low freq Ag
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| Are Bg antigens enzyme destroyed? | No, but chloroquine will remove
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| Most important platelet antigens (5) | 1) GPIa, GPIb, GPIIb, GpIIIa, CD109
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| PLT Ag that 98% of whites express? | HPA-Ia or PLa1-------part of GPIIIa glycoproteins
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| PLT Ags are stimulated by random donor PLTs and can cause ______ & _____ | Post transfusion purpura & neonatal alloimmune thrombocytopenia
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Created by:
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