Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

HTLA & uncommon ab

BB Exam 3

HTLA characteristics -IgG usually non C binder -against high incidence antigens - seen in multiply transfused patients - hides alloantibodies - reacts weakly w/cord cells
Chido/Rodgers system Antigens water soluble; adsorbed onto RBC from plasma--part of C4d on chrome 6-- Ag not well developed at birth--98% white are Cha+
Are Ch & Rg antigens destroyed by enzymes? Yes
Is it necessary to give Ch/Rg antigen negative blood?? No, because the Ab will be neutralized by plasma prior to transfusion
Procedures to ID Ch/Rg antigens (4) 1) Ag neg cells reacted w/plasma 2)enzyme treatment 3)reaction of plasma w/C4d coated RBCs 4)Neutralization w/plasma from Ch/Rg positive person
Plasma inhibition (neutralization) for Ch/Rg -Pooled plasma from 6 pts
What is the control of plasma inhibition? Albumin
Sid (Sda) Antigen 91% of pop has...variable expression...cord cells lack
Sda antibody ALWAYS gives MF reaction (refractile).....Neutralizable with urine from Sda+ person
Do you need to give Sda negative units? No
Bg antigens Class I HLA, strongly expressed on WBCs & PLTs, IgG cline sig, appears as Ab to low freq Ag
Are Bg antigens enzyme destroyed? No, but chloroquine will remove
Most important platelet antigens (5) 1) GPIa, GPIb, GPIIb, GpIIIa, CD109
PLT Ag that 98% of whites express? HPA-Ia or PLa1-------part of GPIIIa glycoproteins
PLT Ags are stimulated by random donor PLTs and can cause ______ & _____ Post transfusion purpura & neonatal alloimmune thrombocytopenia
Created by: aenewsom