Advanced Bloodbank Exam 1, Dr. Smith
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| A donor comes in with a positive syphilis test. What happens? | show 🗑
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| A donor comes in with a positive HIV test. What happens? | show 🗑
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| show | As long as they are afebrile and feeling well, they are accepted.
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| A donor comes in with a history of traveling to Great Britain before 1985. What happens? | show 🗑
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| A 32-year old male donor comes in with a history of having sex with other men. What happens? | show 🗑
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| A 25 year old woman comes in to donate blood and received a butterfly tattoo six months ago. What happens? | show 🗑
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| show | Every 4 weeks
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| A donor has recieved Hepatitis C IG one month ago. What happens? | show 🗑
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| How much should one unit of pRBC's raise a patient's hemoglobin/hematocrit? | show 🗑
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| A donor comes in with a history of recieving growth hormone from pituitary glands. What happens? | show 🗑
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| A donor comes in with a history of taking Tegison (etretinate), a drug used for severe psoriasis. What happens? | show 🗑
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| A donor comes in who has a history of recieving bovine insulin. What happens? | show 🗑
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| show | Indefinite deferral, since there is no specific/sensitive test for malaria.
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| What is the test method for the Human Cytolomegalovirus? | show 🗑
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| The West Nile Virus test looks at which type of genetic material? | show 🗑
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| show | That donor's blood cannot be used for allogenic transfusions
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| If an NAT is reactive, does it have to be repeated? | show 🗑
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| How are donors infected with Babesia screened? | show 🗑
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| show | EIA, RIPA as supplemental
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| show | >10 units pRBCs in 24 hours
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| show | Complications include: Hypovolemia, Shock, Hypothermia, Hyperkalemia, Citrate toxicity, Acidosis, Hemostatic abnormalities, DIC
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| show | An electrolyte solution.
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| What is a colloid? (in terms of transfusion medicine) | show 🗑
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| Why do coagulation problems often happen during massive transfusions? | show 🗑
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| show | Increased PT & APTT, decreased PLTs, decreased fibrinogen, elevated FDP's, elevated D-Dimer
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| What are perflourocarbons? | show 🗑
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| When is granulocyte therapy indicated? | show 🗑
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| What is special about granulocyte donors? | show 🗑
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| What is IVIg? | show 🗑
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| Name some adverse reactions to IVIg. | show 🗑
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| What is WinRho? | show 🗑
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| show | Various immunologic-mediated diseases, and primary and secondary immunodeficiencies
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| Standard collection bags are composed of what? | show 🗑
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| What biochemical changes occur while storing whole blood? | show 🗑
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| show | 1-6 degrees C, monitored at least every 4 hrs
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| What percentage of RBCs must be found in recipient’s circulation 24 hours after transfusion per shelf life criteria? | show 🗑
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| show | Acts as a buffer and maintains 2,3 DPG
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| Whole blood presevered with CPDA-1 has a shelf life of _____? | show 🗑
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| show | 21 days
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| show | The RBC's expire 28 days after irradiation OR their original expiration date, WHICHEVER IS SOONER.
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| show | To reduce the risk of graft vs host disease
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| How long are granulocytes good for? | show 🗑
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| How long is a single unit of CRYO good for post thaw? | show 🗑
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| How long is a pooled unit of CRYO good for post thaw? | show 🗑
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| show | Patients with hypofibrinogenemia
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| What is the QC for cryoprecipitate? | show 🗑
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| What are some indications for using FFP? | show 🗑
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| When is FFP frozen? | show 🗑
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| How long can FFP be stored? | show 🗑
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| show | 24 hrs
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| FFP contains which coag factors? | show 🗑
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| show | No.
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| Why is bacterial contamination a major problem with platelets? | show 🗑
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| show | >6.2
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| show | <5.0 x 10^6 residual WBCs
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| How often can someone donate platelets via plateletpheresis? | show 🗑
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| Name some causes (non-immune and immune)of refractoriness. | show 🗑
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| show | When platelets no longer give expected increase at 1 hour post-transfusion
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| What is the expected raise in platelet count per unit of platelets transfused? | show 🗑
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| show | Surgical: <50,000
Non-surgical: <20,000
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| How many platelets must be in a luekoreduced unit? | show 🗑
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| How does irradiating platelet units affect their expiration date? | show 🗑
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| show | To prevent TACO, in neonates and intrauterine transfusions
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| show | 5 days at RT
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| How long can pooled platelets be stored and at what temperature? | show 🗑
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| How much plasma does a unit of platelets contain? | show 🗑
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| What are some indications for platelet transfusion? | show 🗑
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| show | at least 80% recovery of original RBCs and 70% viability of D-RBCs 24 hours after transfusion
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| show | HCT 80-85%, expiration 24 hours post thaw (2 weeks if closed system is used)
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| show | 20-25 mins, max 40 mins
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| show | within 2 hours
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| show | Within 6 days of collection (rejuventated RBCs must be frozen within 3 days)
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| What is the glycerolization principle? | show 🗑
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| What is the principle of deglycerolization? | show 🗑
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| show | 24 hours
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| What is the value of using washed RBC's? | show 🗑
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| show | <5 x 10^6 (filters must removed at least 99.9% of leukocytes)
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| How many RBC's must remain in a leukocyte-reduced pRBC unit? | show 🗑
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| What are some indications for the use of leukoreduced RBCs? | show 🗑
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| show | Contains pyruvate, inosine, adenine, and phospate, and restores depleted 2,3 DPG and ATP. It is toxic
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| show | Up to 72 hrs post expiration (CPD or CPDA-1 RBCS)
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| show | 24 hours after rejuvenation unless frozen
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| show | <80% HCT, unless additive is used, in which case it may be around 65%
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| show | psychotrophilic bacteria, such as Yersinia enterocolitica. It is not a major problem
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| show | Up to 8 hours
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| show | To treat symptomatic anemia (>30% blood loss, anemia with HgB <8 g/dL)
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| How much does one unit of PRBC in a 70KG adult increase the hemoglobin? The hematocrit? | show 🗑
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| show | Differential centrifugation and gravitational settling
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| What are some ways to prevent a collection lesion? | show 🗑
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| What time interval should blood be collected and why? | show 🗑
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| When is additive added to RBC's? | show 🗑
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| What is the volume of additive added? What is the final hematocrit? | show 🗑
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| show | 21 days
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| How long does CPDA-1 preserved RBCs last? | show 🗑
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| How long do additive solutions extend the shelf life of RBCs? | show 🗑
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| How much preservative solution is inside teh bag? | show 🗑
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| show | Dextrose and sodium bisphosphate
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| show | Citrate
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| What is the effect of 2,3-DPG levels on oxygen release to the tissues? | show 🗑
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