Practice for Hem2 Del-Tech Owens chapter 29
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Most malignancies of the hematopoietic system are acquired __ __. | genetic diseases
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| Most leukocyte malignancies are not __. | localized
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| Most leukocyte malignancies are __ at the initiation of the malignant process. | systemic
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| For most leukocyte neoplasms, the direct cause of the malignancy is __. | unknown
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| Known causes of leukocyte neoplasms include: (4 answers) | environmental toxins, viruses, chemotherapy, familial predisposition
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| The FAB (French-American-British) classification system for leukocyte neoplasia is based primarily on __ and __ __. | morphology and cytochemical staining
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| The WHO (World Health Organization) classification system for leukocyte neoplasia is emphasizes __ and __ changes. | molecular and cytochemical changes
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| A single mutation can lead to a __ transformation of a cell. (Chromosomal transformation = mutation) | malignant
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| Chromosomal transformations in hematologic malignancies illustrate that a single mutation can least to a malignant transformation by disrupting the __ __ of the cell. | molecular machinery
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| Most chromosomal transformations (mutations) in leukemias involve __. | oncogenes
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| Tumor suppressor genes contribute to the process of malignancy only if both alleles have been __ or __. | lost or inactivated
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| The formation of oncogenes or the loss of tumor suppressor genes has molecular effects on the __ and __ of hematologic tissues. | proliferation and differentiation
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| The 5 categories of treatment for leukocyte neoplasms are: | chemo, radiation, supportive, targetd, stem cell transplantation
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| Which virus is known to cause lymphoid malignancies in humans? | Epstein-Barr (mono)
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| Tumor suppressor genes cause cancers (like leukemia) when mutations result in a failure to __ __ __. | prevent malignant processes
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| Oncogenes can be said to react in a dominant fashion because a mutation in a __ __ is enough for malignancy to develop. | single allele
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| True of false: Acceleration of DNA catabolism is one of the cellular abnormalities produced by oncogenes. | false
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| Three cell abnormalities caused by oncogenes are: | apoptotic failure, suppression of DNA transcription, disruption of cell cycle processes
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| What are the 2 major subgroups of chemotherapeutic agents? | phase specific and phase nonspecific
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| G-CSF is a supportive treatment for leukemia because it reduces the risk of __. | infection
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| Imatinib is a __ __ treatment for leukemia. | targeted therapy
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| Monoclonal antibodies can kill cancer cells by what 3 mechanisms? | 1) binding to the cancer cells and causing the immune system to destroy them 2) activating complement on the cell's surface 3) increasing the rate of apoptosis in the cancer cells
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| What 3 areas of the body are stem cells harvested from for transplantation? | 1) bone marrow 2) peripheral blood 3) umbilical cord blood
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| Allogeneic transplantation has a __ long-term success rate than autologuous bone marrow transplantation. | better
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