SB82 ABSITE Oncology - loosely taken from Fiser's ABSITE Review
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Most common cancer in women | Breast cancer
🗑
|
||||
| Most common cause of cancer-related death in women | Lung cancer
🗑
|
||||
| Most common cause of cancer-related death in men | Lung cancer
🗑
|
||||
| PET detects areas of high-metabolic rate, as illustrated by uptake of ___________________ | Fluorodeoxyglucose
🗑
|
||||
| T cells need this to be able to attack tumor cells ____________ | MHC complex
🗑
|
||||
| These immune cells can attack cancer cells independently ______________ | Natural killer cells
🗑
|
||||
| Tissue abnormality causing increased NUMBER of cells __________ | Hyperplasia
🗑
|
||||
| Tissue abnormality causing replacement of one tissue with another (as in GERD causing esophageal squamous epithelium to be replaced with gastric columnar cells) ____________ | Metaplasia
🗑
|
||||
| Tissue abnormality causing altered size, shape, and organization of cells (as in Barrett’s esophagus) _______________ | Dysplasia
🗑
|
||||
| Cancer associated with CEA ___________ | Colon
🗑
|
||||
| Cancer(s) associated with AFP ___________ | Liver, non-seminomatous germ cell tumors
🗑
|
||||
| Cancer(s) associated with Ca 19-9 ___________ | pancreas, biliary cancer
🗑
|
||||
| Cancer associated with CA 125 ________________ | Ovarian
🗑
|
||||
| Cancer(s) associated with beta HCG _____________ | testicular cancer and choriocarcinoma
🗑
|
||||
| Cancer associated with elevated PSA _____________ | Prostate
🗑
|
||||
| Cancer(s) associated with neuron-specific enolase (NSE) ______________ | small cell lung cancer, neuroblastoma, merkel cell carcinoma
🗑
|
||||
| The time between the development of the cancer and when it becomes clinically detectable is the _____________ | Latency period
🗑
|
||||
| EBV retrovirus is associated with which cancers? | Burkitt’s lymphoma and nasopharyngeal carcinoma
🗑
|
||||
| Cancer associated with HPV ___________ | Cervical
🗑
|
||||
| Cancer associated with H. pylori _____________ | Gastric
🗑
|
||||
| Cancer associated with Hep B ____________ | Hepatocellular carcinoma
🗑
|
||||
| Cancer(s) associated with HHV-8 (human herpes virus 8) _____________ | Kaposi sarcoma and primary effusion lymphoma
🗑
|
||||
| Cancer(s) associated with Hep C ______________ | Splenic lymphoma and HCC
🗑
|
||||
| Definition of “proto-oncogenes” | Human genes with malignant potential
🗑
|
||||
| The phase of the cell cycle where the cell is most vulnerable to radiation ___________ | M phase
🗑
|
||||
| Damage to a cell through radiation is due to what process? | Formation of oxygen radicals
🗑
|
||||
| High-energy radiation preserves what body structure? _________ | Skin
🗑
|
||||
| Fractionated radiation has what benefits (three "R"s)? | Allows Repair of normal cells, allows Re-oxygenation of the tumor, and allows Redistribution of the cells in the cell cycle
🗑
|
||||
| Examples of very radiosensitive tumors (2) | Seminomas, lymphomas
🗑
|
||||
| Examples of very radio-resistant tumors (2) | Epithelial cancers, sarcomas
🗑
|
||||
| Placement of a source of radiation in or next to a tumor to provide high, concentrated doses of radiation is called ____________ | Brachytherapy
🗑
|
||||
| Cell-cycle non-specific agents exhibit a ___________ response to cell killing | Linear
🗑
|
||||
| Mechanism of taxol | Promotes microtubule formation and stabilization so cells cannot divide; cells rupture
🗑
|
||||
| Side effects of bleomycin and busulfan __________ | Pulmonary fibrosis
🗑
|
||||
| Examples of microtubule-inhibiting chemotherapeutic agents _____________ | Vincristine, vinblastine
🗑
|
||||
| Active metabolite in of cyclophosphamide ________ | Acrolein
🗑
|
||||
| Side effects of cyclophosphamide use (3) | Gonadal dysfunction, SIADH, hemorrhagic cystitis
🗑
|
||||
| Medication that can alleviate hemorrhagic cystitis due to cyclophosphamide ____________ | Mesna
🗑
|
||||
| An antihelminthic drug thought to stimulate the immune response against cancer _________ | Levamisole
🗑
|
||||
| Methotrexate inhibits purine synthesis, and ultimately DNA synthesis, by inhibiting this enzyme ______________ | Dihydrofolate reductase
🗑
|
||||
| What is the effect of leukovorin on the effect of 5-FU? | Increases the toxicity of 5-FU
🗑
|
||||
| What chemotherapeutic agent inhibits topoisomerase (which normally unwinds DNA)? __________ | Etoposide
🗑
|
||||
| Agent that causes cardiotoxicity due to formation of oxygen radicals ____________ | Doxorubicin
🗑
|
||||
| Purpose of GCSF in cancer treatment | Helps neutrophil recovery after chemotherapy
🗑
|
||||
| Side effect of granulocyte-colony-stimulating factor | Sweet’s syndrome (acute febrile neutropenic dermatitis)
🗑
|
||||
| Proto-oncogenes and their associated defect: ras _____________ | G protein
🗑
|
||||
| Proto-oncogenes and their associated defect: src _____________ | Tyrosine kinase
🗑
|
||||
| Proto-oncogenes and their associated defect: sis _____________ | platelet-derived growth factor
🗑
|
||||
| Proto-oncogenes and their associated defect: erb B _____________ | Epidermal growth factor
🗑
|
||||
| Types of cancer associated with Li-Fraumeni syndrome | Childhood sarcomas, breast cancer, brain tumors, leukemia, adrenal cancer
🗑
|
||||
| Cancer associated with the Ret proto-oncogene _____________ | Medullary thyroid cancer
🗑
|
||||
| Patients with Ret mutation plus positive family history of MEN syndrome should have this intervention __________ | Prophylactic total thyroidectomy (90% get medullary thyroid cancer)
🗑
|
||||
| The gene thought to comprise the “first hit” in development of colon cancer _________ | APC
🗑
|
||||
| The primary cancer associated with palpable axillary lymph node ______________ | Lymphoma
🗑
|
||||
| Cancer associated with suspicious periumbilical node ____________ | Pancreatic
🗑
|
||||
| Primary cause of bone metastases ________ | Breast cancer
🗑
|
||||
| Primary cause of metastases to the small bowel ________ | Melanoma
🗑
|
||||
| Survival rate from fully-resected colon cancer liver mets ___________ | 25% after 5 years
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
StudyBug82
Popular Surgery sets