Chapter 12 review on Leukopoiesis DelTech Owens
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| What is the development of white blood cells called? | Leukopoiesis
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| Where does leukopoiesis occur? | The medullary cavity (bone marrow). Some lymphocytes develop in the thymus (T cells)
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| What is another word for white blood cells? | Leukocyte
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| How are leukocytes categorized? | By 1) specific function 2) site of origin 3) morphology
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| What are the 2 basic types of leukocytes? | Granular and agranular
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| Which series of leukocytes has granules in it? (Granular) | Myelocytic series
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| Which series of leukocytes has no granules in it? (Agranular) | Lymphocytes and monocytes
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| Where are the 4 locations for granulocytes in the body? | 1) bone marrow 2) circulating blood 3) marginal pool/endothelial lining 4) tissues
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| What is the first stage of a granulocyte's development? | Myeloblast
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| What is the 2nd stage of a granulocyte's development? | Promyelocyte
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| What is the 3rd stage of a granulocyte's development? | Neutrophil Myelocyte
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| What is the 4th stage of a granulocyte's development? | Neutrophilic Metamyelocyte
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| What is the 5th stage of a granulocyte's development? | Neutrophilic Band
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| What is the 6th stage of a granulocyte's development? | Neutrophilic Segment
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| What is the primary function of a neutrophilic segment cell? | Phagocytosis
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| What are the 3 stages of phagocytosis? | 1) migration and diapedsis 2) opsonization and recognition 3)phagocytosis, killing and digestion
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| __ is the movement of the seg through the vessel wall. | Diapedesis
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| Directional migration to the site of an injury is called __. | Chemotaxis
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| Opsonization is the mechanism of __ and attachment to the organisms to be ingested during phagocytosis. | recognition
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| After a bacteria is coated in immunoglobulins and complements, it is referred to as __. | opsonin
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| When a neutrophil attacks an invader, its cytoplasm forms a __ that surrounds the microorganism. | pseudopod
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| After a neutrophil has formed a pseudopod around an invading microorganism, the resulting vacuole is called a __. | phagosome
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| Once a neutrophil has enveloped an invading microorganism, its cytoplasmic __ migrate to the phagosome/vacuole. | granules
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| A __ has red-eosin secondary granules. | eosinophil
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| A __ has large, deep purple to black granules. | basophil
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| __ cells are really just basophils in tissue. | Mast
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| Monocytes and macrophages are __. (With or without granules?) | agranular
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| The first stage of the monocytic/macrophage line is a __. | monoblast
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| The 2nd stage of the monocytic/macrophage line is a __. | promonocyte
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| The 3rd stage of the monocytic/macrophage line is a __. | monocyte
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| The 4th stage of the monocytic/macrophage line is a __. | macrophage
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| Monoblasts are usually seen in the __ __. | bone marrow
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| Monoblasts can also be found in the __. | spleen
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| True or false: Monoblasts are granular white blood cells? | False
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| Promonocytes are the same size as a __. | monoblast
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| __ destroy old red blood cells. | monocytes
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| Monocytes migrate into tissue to become __. | macrophages
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| Macrophages are basically __ in the tissue. | monocytes
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| __ are anti-tumor cells. | macrophages
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| Lymphocytes develop in what 4 places? | 1) bone marrow 2) lymphatic system 3) spleen 4) thymus
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| Lymphocytes can live from __ to __ years. | five to ten years
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| Lymphocytes that live 5 to 10 years are called __ cells. | memory
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| Most white blood cells only live __ to __ days. | seven to ten days
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| The thymus develops __ cells. | T cells
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| __ __ develops B cells. | Bone marrow
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| Once cells develop into T or B cells, they go to the secondary lymphatic tissues, which are what 4 areas? | 1) spleen 2) tonsils 3) lymph nodes 4) cells that respond to specific antigens
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| Reactive lymphocytes have a __ __ appearance. | fried egg
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| The first stage of lymphocytic cell maturation is called a __. | lymphoblast
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| The 2nd stage of lymphocytic cell maturation is called a __. | prolymphocyte
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| The 3rd stage of lymphocytic cell maturation is called a __. | mature lymphocyte
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| A lymphoblast has a __ cytoplasm. | blue
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| a prolymphocyte has a __ __ cytoplasm. | light blue
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| B cells transform into __ cells for antibody protection. | plasma
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| Receptors or markers that come and go depending on development and need are called __ __. | T cells
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| CD4 T cells are also called __ __. | helper cells
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| CD8 T cells are also called __ __. | suppressor cells
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| Lymphoctyes are __ of the immune system. | regulators
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| Once a lymphocyte is activated to fight foreign objects, it becomes a __ lymphocyte. | reactive
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| WBCs that are granulitic usually end with the suffix __. | phil
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| WBCs that are agranulitic usually end with the suffix __. | cyte
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| Lymphocytes are classified by __ __. | flow cytometry
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| CD stands for __ __ __. | cluster of differentiation
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| What are lymphocytes classified for? | lymphotytic leukemias and lymphomas
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| Lymphoblasts in the circulating blood are only seen in patients with __. | leukemia
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| Plasma cells have a __ __ cytoplasm with a pale area near the nucleus. | dark blue
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| If the immune system doesn't react quickly enough to an invader, macrophages release __. | IL-1
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| If the immune system doesn't react quickly enough to an invader, T cells release factors that increase development of antigen specific _ __ and __ T cells. | B lymphs and cytotoxic T cells
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| BCDF stands for __. | B Cell Differentiation Factor
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| B cells with the help of IL-1 and BCDFs promote differentiating into __ __. | plasma cells
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| Plasma cells start production of __ in fighting off invaders. | immunoglobulins
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| A foreign object in the body that produces an immune response is called an __. | antigen
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| Lymphocytes, once activated, change into __ __ to fight off antigens. | reactive lymphocytes
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