For test in Hematology 1 DelTech Owens campus chapter 9 through 11 and 16
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| What is the main function of RBCs? | To deliver oxygen.
🗑
|
||||
| You need what kind of iron in your body so your RBCs can transport oxygen? | Fe 2+
🗑
|
||||
| What pathway assists in maintaining Fe 2? | Methemoglobin reductase pathway
🗑
|
||||
| Glucose is required to generate __. | ATP
🗑
|
||||
| Glucose enters the erythrocyte by __ __ __. | Facilitated membrane transport
🗑
|
||||
| When we are born, are bones have only __ marrow. | red
🗑
|
||||
| When does yellow marrow begin to replace the red marrow in the long bones of extremities? | 5th to 7th year
🗑
|
||||
| Adult hematopoietic tissue is limited to the __ skeleton and the __ portions of the extremities. | axial, proximal
🗑
|
||||
| Bone marrow sampling will depend on the __ of the patient. | age
🗑
|
||||
| The __ crest is a source of red marrow in adults. | iliac
🗑
|
||||
| What is the favored site for obtaining bone marrow aspirate and core biopsy specimen? | Posterior iliac crest
🗑
|
||||
| A bone marrow needle is technically called a __ __. | jamshidi needle
🗑
|
||||
| Iron is absorbed in the __ and the __. | duodinum, jejunum (both are sections of the small intestine)
🗑
|
||||
| What is a carrier protein for iron which goes to hematopoietic tissue? | Transferrin (iron enters circulation bound to transferrin)
🗑
|
||||
| Some iron is temporarily stored as __. | Ferritin
🗑
|
||||
| What are the 3 principal regulators of iron? | transferrin, transferrin receptor, ferritin
🗑
|
||||
| What are the 3 regulators regulated by? | Iron-responsive element binding protein (IRE-BP)
🗑
|
||||
| What is transferrin called when there is no iron attached? | apoferritin
🗑
|
||||
| Where is transferrin produced? | the liver
🗑
|
||||
| Iron stored in degraded Ferritin is called __. | Hemosiderin. (The iron within deposits of hemosiderin is very poorly available to supply iron when needed.)
🗑
|
||||
| In what organs is iron stored? | liver, bone marrow, and spleen
🗑
|
||||
| What does a measurement of Serum Ferritin indicate? | Iron stores in the body
🗑
|
||||
| What does a measurement of Serum Iron indicate? | Tissue iron supply
🗑
|
||||
| What does a measurement of TIBC/transferrin indicate? | Tissue iron supply
🗑
|
||||
| What does a measurement of bone marrow sideroblast count indicate? | Functional iron available
🗑
|
||||
| What is the main component of RBCs? | Hemoglobin
🗑
|
||||
| What gives blood it's red color? | Heme
🗑
|
||||
| Heme biosynthesis happens where? | mitochondria & cytoplasm of erythrocyte precursors (from rubriblast to retics) in the bone marrow.
🗑
|
||||
| Mature erythrocytes cannot synthesize __. | Heme
🗑
|
||||
| What vitamin does heme biosynthesis require? | B6
🗑
|
||||
| Heme biosynthesis begins with condensation of _ and __. | glycine, coenzyme A
🗑
|
||||
| During heme biosynthesis, glycine and coenzyme A (CoA) are catalyzed by __ __ synthase to form __. | delta ALA synthase, ALA
🗑
|
||||
| What plasma protein carries iron to the developing RBCs? | Transferrin
🗑
|
||||
| Excess iron aggregates in the cytoplasm as __. | ferritin
🗑
|
||||
| What unites with protoporphyrin 9 to make heme? | iron
🗑
|
||||
| Iron and protoporphyrin 9 combine in the presence of __ to create heme. | ferrochelatase
🗑
|
||||
| Excess accumulated iron the nucleated RBC (NRBC) results in a cell called a __. | sideroblast
🗑
|
||||
| A sideroblast is an anucleated RBC with excess __. | iron
🗑
|
||||
| The most common combo of chains that form hemoglobin A are __ and __. | two alpha, two beta
🗑
|
||||
| Hgb A2 contains 2 __ and 2 __ chains. | alpha, delta
🗑
|
||||
| Hgb F contains 2 __ and 2 __. | alpha, gamma
🗑
|
||||
| What 2 things combine to form hemoglobin? | heme and globin
🗑
|
||||
| What oxygen binding heme protein binds oxygen better than hgb? | myoglobin
🗑
|
||||
| If the oxygen dissociation curve shifts to the left, you need __ oxygen. | less oxygen
🗑
|
||||
| If the oxygen dissociation curve shifts to the left, alkalyne levels go __. | higher
🗑
|
||||
| If the oxygen dissociation curve shifts to the right, you need __ oxygen. | more
🗑
|
||||
| Normally a pO2 of __ mm is needed to saturate 50% of Hgb (P50). | 27
🗑
|
||||
| An increase in PH level is generally __ (good or bad?) | good
🗑
|
||||
| What can cause an increase in PH levels? | blood transfusion, decreased body temp, Hgb F
🗑
|
||||
| A decrease in PH level is generally __ (good or bad?) | bad
🗑
|
||||
| What can cause a decrease in PH levels? | hypoxia, increase in body temp, pulmonary problems, several anemia
🗑
|
||||
| Hgb F results in an __ in oxygen saturation and affinity. | increase
🗑
|
||||
| Methemoglobin is incapable of combining with __. | oxygen
🗑
|
||||
| Sulfhgb can be __ and contains sulfur. | fatal
🗑
|
||||
| Cyanmethehemeglobin is used to quantify Hb by reading the color change of blood at __ nm and comparing it with a standard. | 540
🗑
|
||||
| What does ADP stand for? | adenosine diphosphate
🗑
|
||||
| What does ATP stand for? | adenosine triphosphate
🗑
|
||||
| What comes off the Embden-Meyerhof pathway? | 2,3-DPG(BPG)
🗑
|
||||
| The Methemeglobin reductase pathway maintains __ in the ferrous (Fe 2+) state. | iron
🗑
|
||||
| The Rapoport pathway is __? | part of the glycolytic pathway of human erythrocytesan and an important regulator of the affinity of hemoglobin for oxygen.
🗑
|
||||
| Without __, you can't keep oxygen in RBCs. | Fe 2+
🗑
|
||||
| If the __ __ shunt id deficient, Heinz bodies may result. | Hexose Monophosphate shunt
🗑
|
||||
| The Leubering-Rapaport shunt permits the accumulation of __. | 2,3-DPG
🗑
|
||||
| What is essential for maintaining oxygen tension? | 2,3-DPG
🗑
|
||||
| Anaerobic glycolysis begins with __, a glycolytic enzyme. | hexokinase
🗑
|
||||
| Anaerobic glycolysis ends with __. | Pyruvate kinase
🗑
|
||||
| The main physiological functions of the RBC membrane are to maintain cell shape __ for osmotic balance. | deformability
🗑
|
||||
| The RBC membrane acts as a supporting __ system for surface antigens. | skeletal
🗑
|
||||
| The peripheral proteins of the RBC membrane are __, __, __, __, and protein __. | spectrin, actin, GPD, ankyrin, protein 4 (SAGAP4)
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
IsaacJ
Popular Laboratory Science sets