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Hem1 Chp9 test DelTe

For test in Hematology 1 DelTech Owens campus chapter 9 through 11 and 16

QuestionAnswer
What is the main function of RBCs? To deliver oxygen.
You need what kind of iron in your body so your RBCs can transport oxygen? Fe 2+
What pathway assists in maintaining Fe 2? Methemoglobin reductase pathway
Glucose is required to generate __. ATP
Glucose enters the erythrocyte by __ __ __. Facilitated membrane transport
When we are born, are bones have only __ marrow. red
When does yellow marrow begin to replace the red marrow in the long bones of extremities? 5th to 7th year
Adult hematopoietic tissue is limited to the __ skeleton and the __ portions of the extremities. axial, proximal
Bone marrow sampling will depend on the __ of the patient. age
The __ crest is a source of red marrow in adults. iliac
What is the favored site for obtaining bone marrow aspirate and core biopsy specimen? Posterior iliac crest
A bone marrow needle is technically called a __ __. jamshidi needle
Iron is absorbed in the __ and the __. duodinum, jejunum (both are sections of the small intestine)
What is a carrier protein for iron which goes to hematopoietic tissue? Transferrin (iron enters circulation bound to transferrin)
Some iron is temporarily stored as __. Ferritin
What are the 3 principal regulators of iron? transferrin, transferrin receptor, ferritin
What are the 3 regulators regulated by? Iron-responsive element binding protein (IRE-BP)
What is transferrin called when there is no iron attached? apoferritin
Where is transferrin produced? the liver
Iron stored in degraded Ferritin is called __. Hemosiderin. (The iron within deposits of hemosiderin is very poorly available to supply iron when needed.)
In what organs is iron stored? liver, bone marrow, and spleen
What does a measurement of Serum Ferritin indicate? Iron stores in the body
What does a measurement of Serum Iron indicate? Tissue iron supply
What does a measurement of TIBC/transferrin indicate? Tissue iron supply
What does a measurement of bone marrow sideroblast count indicate? Functional iron available
What is the main component of RBCs? Hemoglobin
What gives blood it's red color? Heme
Heme biosynthesis happens where? mitochondria & cytoplasm of erythrocyte precursors (from rubriblast to retics) in the bone marrow.
Mature erythrocytes cannot synthesize __. Heme
What vitamin does heme biosynthesis require? B6
Heme biosynthesis begins with condensation of _ and __. glycine, coenzyme A
During heme biosynthesis, glycine and coenzyme A (CoA) are catalyzed by __ __ synthase to form __. delta ALA synthase, ALA
What plasma protein carries iron to the developing RBCs? Transferrin
Excess iron aggregates in the cytoplasm as __. ferritin
What unites with protoporphyrin 9 to make heme? iron
Iron and protoporphyrin 9 combine in the presence of __ to create heme. ferrochelatase
Excess accumulated iron the nucleated RBC (NRBC) results in a cell called a __. sideroblast
A sideroblast is an anucleated RBC with excess __. iron
The most common combo of chains that form hemoglobin A are __ and __. two alpha, two beta
Hgb A2 contains 2 __ and 2 __ chains. alpha, delta
Hgb F contains 2 __ and 2 __. alpha, gamma
What 2 things combine to form hemoglobin? heme and globin
What oxygen binding heme protein binds oxygen better than hgb? myoglobin
If the oxygen dissociation curve shifts to the left, you need __ oxygen. less oxygen
If the oxygen dissociation curve shifts to the left, alkalyne levels go __. higher
If the oxygen dissociation curve shifts to the right, you need __ oxygen. more
Normally a pO2 of __ mm is needed to saturate 50% of Hgb (P50). 27
An increase in PH level is generally __ (good or bad?) good
What can cause an increase in PH levels? blood transfusion, decreased body temp, Hgb F
A decrease in PH level is generally __ (good or bad?) bad
What can cause a decrease in PH levels? hypoxia, increase in body temp, pulmonary problems, several anemia
Hgb F results in an __ in oxygen saturation and affinity. increase
Methemoglobin is incapable of combining with __. oxygen
Sulfhgb can be __ and contains sulfur. fatal
Cyanmethehemeglobin is used to quantify Hb by reading the color change of blood at __ nm and comparing it with a standard. 540
What does ADP stand for? adenosine diphosphate
What does ATP stand for? adenosine triphosphate
What comes off the Embden-Meyerhof pathway? 2,3-DPG(BPG)
The Methemeglobin reductase pathway maintains __ in the ferrous (Fe 2+) state. iron
The Rapoport pathway is __? part of the glycolytic pathway of human erythrocytesan and an important regulator of the affinity of hemoglobin for oxygen.
Without __, you can't keep oxygen in RBCs. Fe 2+
If the __ __ shunt id deficient, Heinz bodies may result. Hexose Monophosphate shunt
The Leubering-Rapaport shunt permits the accumulation of __. 2,3-DPG
What is essential for maintaining oxygen tension? 2,3-DPG
Anaerobic glycolysis begins with __, a glycolytic enzyme. hexokinase
Anaerobic glycolysis ends with __. Pyruvate kinase
The main physiological functions of the RBC membrane are to maintain cell shape __ for osmotic balance. deformability
The RBC membrane acts as a supporting __ system for surface antigens. skeletal
The peripheral proteins of the RBC membrane are __, __, __, __, and protein __. spectrin, actin, GPD, ankyrin, protein 4 (SAGAP4)
Created by: IsaacJ