Hematology1 test Chpt8 Erythrocyte Prod and Dest
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| Erythrocytes are __ __ cells. | Red blood cells
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| Normal RBCs developing in bone marrow are called __. | Normoblasts
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| What is a megaloblast? | An unusually large erythroblast.
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| What does the presence of megaloblasts indicate? | Vitamin B12 deficiency and/or folic acid deficiency
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| The maturation of normoblasts into true erythrocytes is controled by a __ __ __. | feedback loop mechanism
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| An erythroblast is __? (Define it) | an RBC that retains a nucleus and the precursor of an erythrocyte.
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| The presence of megaloblasts is called? | Megaloblastic anemia
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| What are the criteria used in identifying erythroid precursors? | 1. Good stain and smear 2. Use of Wright's stain 3. Determine stage of maturation 4. Examine cell nucleus, cytoplasm, and size.
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| The first stage in the maturation sequence of RBCs is called a __ or a __. | Rubriblast or a pronormoblast
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| The 2nd stage in the maturation sequence of RBCs is called a __ or a __. | Prorubricyte or a basophilic normoblast
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| The 3rd stage in the maturation sequence of RBCs is called a __ or a __. | Rubricyte or a polychromatic normoblast
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| The 4th stage in the maturation sequence of RBCs is called a __ or a __. | Metarubricyte or an orthochromic normoblast
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| The 5th stage in the maturation sequence of RBCs is called a __ or a __. | Reticulocyte or a polychromatophilc rbc
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| The 6th stage in the maturation sequence of RBCs is called a __. | Mature erythrocyte
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| What type of stain do you use to spot a reticulocyte? | New methylene blue
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| What part of the cells gives a retic stained with new methylene blue the appearance of blue dots? | Reticulum
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| New methylene blue is what kind of stain? | Supravital
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| Retics stay how many days in the bone marrow? | 2-3
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| How long do retics circulate in our blood stream? | 1 day
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| For every 100 erythroctyes, there are how many retics? | 1
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| Percentage-wise, what is the normal range of reticulocytes in an adult human body? | 0.5 - 1.5%
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| What is the last stage in the maturation of an RBC before it becomes an erythrocyte? | Reticulocyte
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| How long does it take a stem cell to develop into a full erythrocyte? | 4 - 5 days
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| What is the average diameter of a healthy erythrocyte? | 7 um
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| What is the main function of an erythrocyte? | To deliver oxygen throughout the body
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| What percentage of a mature erythrocyte is made of hgb (hemoglobin)? | 90%
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| Erythropoietin (the hormone that controls the rate of erythrocyte production) increases under what 3 factors? | 1. hemorrhage, 2. increased RBC destruction, 3. other factors reducing oxygen tension
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| What part of the kidney produces erythropoietin? | Peritubular interstitial cells
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| Erythropoietin acts on the __ __. | Bone marrow
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| What does it mean when a patient has aplasia? | Their body isn't responding to erythropoietin.
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| Apoptosis is __ __ __. | Programmed cell death
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| Shift retics have __ __ due to early release. | more RNA
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| Iron is used in the synthesis of __. | hemoglobin
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| The __ __ __ is a system of fixed macrophages located all over the body, especially the spleen. | reticuloendothelial system (RES)
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| As erythrocytes age, their shape becomes more __. | spherical
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| As erythrocytes age, they accumulate __ due to decreased enzyme activity. | methg, or methemoglobin
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| Learn the chart about Extravascular hemolysis!! |
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