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Hem1 Chp8 Erythrocyt

Hematology1 test Chpt8 Erythrocyte Prod and Dest

Erythrocytes are __ __ cells. Red blood cells
Normal RBCs developing in bone marrow are called __. Normoblasts
What is a megaloblast? An unusually large erythroblast.
What does the presence of megaloblasts indicate? Vitamin B12 deficiency and/or folic acid deficiency
The maturation of normoblasts into true erythrocytes is controled by a __ __ __. feedback loop mechanism
An erythroblast is __? (Define it) an RBC that retains a nucleus and the precursor of an erythrocyte.
The presence of megaloblasts is called? Megaloblastic anemia
What are the criteria used in identifying erythroid precursors? 1. Good stain and smear 2. Use of Wright's stain 3. Determine stage of maturation 4. Examine cell nucleus, cytoplasm, and size.
The first stage in the maturation sequence of RBCs is called a __ or a __. Rubriblast or a pronormoblast
The 2nd stage in the maturation sequence of RBCs is called a __ or a __. Prorubricyte or a basophilic normoblast
The 3rd stage in the maturation sequence of RBCs is called a __ or a __. Rubricyte or a polychromatic normoblast
The 4th stage in the maturation sequence of RBCs is called a __ or a __. Metarubricyte or an orthochromic normoblast
The 5th stage in the maturation sequence of RBCs is called a __ or a __. Reticulocyte or a polychromatophilc rbc
The 6th stage in the maturation sequence of RBCs is called a __. Mature erythrocyte
What type of stain do you use to spot a reticulocyte? New methylene blue
What part of the cells gives a retic stained with new methylene blue the appearance of blue dots? Reticulum
New methylene blue is what kind of stain? Supravital
Retics stay how many days in the bone marrow? 2-3
How long do retics circulate in our blood stream? 1 day
For every 100 erythroctyes, there are how many retics? 1
Percentage-wise, what is the normal range of reticulocytes in an adult human body? 0.5 - 1.5%
What is the last stage in the maturation of an RBC before it becomes an erythrocyte? Reticulocyte
How long does it take a stem cell to develop into a full erythrocyte? 4 - 5 days
What is the average diameter of a healthy erythrocyte? 7 um
What is the main function of an erythrocyte? To deliver oxygen throughout the body
What percentage of a mature erythrocyte is made of hgb (hemoglobin)? 90%
Erythropoietin (the hormone that controls the rate of erythrocyte production) increases under what 3 factors? 1. hemorrhage, 2. increased RBC destruction, 3. other factors reducing oxygen tension
What part of the kidney produces erythropoietin? Peritubular interstitial cells
Erythropoietin acts on the __ __. Bone marrow
What does it mean when a patient has aplasia? Their body isn't responding to erythropoietin.
Apoptosis is __ __ __. Programmed cell death
Shift retics have __ __ due to early release. more RNA
Iron is used in the synthesis of __. hemoglobin
The __ __ __ is a system of fixed macrophages located all over the body, especially the spleen. reticuloendothelial system (RES)
As erythrocytes age, their shape becomes more __. spherical
As erythrocytes age, they accumulate __ due to decreased enzyme activity. methg, or methemoglobin
Learn the chart about Extravascular hemolysis!!
Created by: IsaacJ