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Preparing for test (chapters 7-11&16) in Hematology 1 DelTech Owens

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Question
Answer
What do you call the formation of blood cells?   Hematopoiesis  
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How many phases of hematopoiesis are there in our lives?   3  
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The 2nd phase of hematopoiesis is called __.   Hepatic phase  
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What 4 organs generate blood cells during the Hepatic phase?   Spleen, thymus, liver, lymph nodes (STLLn, or "Still-in")  
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The 1st phase of hematopoiesis is called __.   Mesoblastic phase (or Yolk Sac Phase)  
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When does the mesoblastic phase begin?   2-3 weeks after fertilization  
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The mesoblastic phase ends after __ weeks.   6  
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During the mesoblastic phase of Hematopoiesis, stem cells from the yolk sac differentiate into primitive __.   Erythroblasts  
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What is an erythroblast?   Primitive pluripotential cells that are precursors of all blood cell lines.  
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What is the first lymphatic organ to develop? (This happens during the hepatic phase)   The thymus  
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Where do B cells develop in the hepatic phase?   The spleen and kidney  
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What phase does production of megakaryocytes begin in?   Hepatic phase  
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What is lymphopoiesis?   The generation of lymphocytes, more formally called lymphoid hematopoiesis.  
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The spleen is almost the sole site of __ during the hepatic phase.   lymphopoiesis  
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What is the 3rd phase of hematopoiesis?   Medullary phase (or myeloid phase)  
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When does the medullary phase begin?   Five months  
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Bone marrow activity increases tremendously during the __ phase.   Medullary phase  
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After __ months, the bone marrow is the primary source of hematopoiesis.   6  
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CSF stands for __.   colony stimulating factors  
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What do colony stimulating factors do?   Cause the cells to proliferate and differentiate into specific kinds of blood cells  
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Under hypoxic conditions, the __ will produce and secrete erythropoietin to increase the production of red blood cells.   Kidney  
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What is the most common cause of anemia?   Iron deficiency  
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The kind of bone marrow that produces stem cells and all blood cell lines is called __ __ __.   Red bone marrow  
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Megakaryocytes are __ in size and produce __.   Large in size and produce platelets.  
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Macrophages are __ blood cells.   White  
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What color is the bone marrow of 3 year old?   Entirely red  
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At what age does a child's bone marrow start to turn from red to (partially) yellow?   4 years of age. The process ends around 7 years of age.  
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Adult red marrow is restricted to -- -- -- -- -- -- --.   Flat bones, sternum, vertebrae, pelvis, ribs, skull, proximal ends of long bones.  
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If the body needs to produce more blood cells than the red bone marrow can provide, it can revert to the __ and has __ __ __ as a reserve.   The spleen, has yellow marrow-fat as a reserve.  
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How long do RBCs live?   120 days  
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What is the normal percentage rate of loss for RBCs in the body per day?   2%  
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Granulocytes are __ blood cells characterized by the presence of __ in their cytoplasm.   White blood cells, granules in their cytoplasm  
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Adult bone marrow tissue consists of __% marrow and __% fat.   50, 50  
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In a patient with leukemia, the ratio of __ marrow to fat increases dramatically.   red  
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Phagocytic __ cells in the spleen, liver, and other strategic locations "eat" pathogens as well as eliminating debris from the blood.   macrophage  
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The __ is the storage cite for platelets.   spleen  
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Splenomegaly is __?   an enlargement of the spleen  
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What does splenomegaly indicate?   leukemia, lymphomas, RBC problems  
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Where does differentiation of T cells occur?   Thymus  
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As you get older, the thymus __.   Shrinks  
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Lymph nodes are located __ __ in the body.   almost everywhere  
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B cells are created in the __ __.   lymph nodes  
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What are the 3 main functions of lymph nodes?   1. Form new lymphocytes, 2. process specific antibodies (immunoglobulins), 3. filer debris and bacteria  
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What is the monophylectic theory?   All blood cells are derived from a common stem cell.  
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What is the polyphyletic theory?   There's a separate and distinct stem cell compartment for each blood cell type.  
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Two major types of stem cells are:   noncommitted (also called undifferentiated) and multipotential  
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What kind of cell is responsible for the stimulation or inhibition of blood cells?   cytokine  
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Another word for white blood cells?   Leukocytes  
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What are the 2 main types of white blood cells   myelocytes and lymphocytes  
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What is leukipoietin?   a hypothetical substance presumed to be the humoral means of regulating leukopoiesis.  
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What is thrombopoietin?   A colony-stimulating factor that regulates production of platelets.  
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What kind of cells platelets come from?   Megakaryocytes  
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Where is erythropoietin produced?   The kidney  
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