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Hem1 Chp7 Hematopoie

Preparing for test (chapters 7-11&16) in Hematology 1 DelTech Owens

What do you call the formation of blood cells? Hematopoiesis
How many phases of hematopoiesis are there in our lives? 3
The 2nd phase of hematopoiesis is called __. Hepatic phase
What 4 organs generate blood cells during the Hepatic phase? Spleen, thymus, liver, lymph nodes (STLLn, or "Still-in")
The 1st phase of hematopoiesis is called __. Mesoblastic phase (or Yolk Sac Phase)
When does the mesoblastic phase begin? 2-3 weeks after fertilization
The mesoblastic phase ends after __ weeks. 6
During the mesoblastic phase of Hematopoiesis, stem cells from the yolk sac differentiate into primitive __. Erythroblasts
What is an erythroblast? Primitive pluripotential cells that are precursors of all blood cell lines.
What is the first lymphatic organ to develop? (This happens during the hepatic phase) The thymus
Where do B cells develop in the hepatic phase? The spleen and kidney
What phase does production of megakaryocytes begin in? Hepatic phase
What is lymphopoiesis? The generation of lymphocytes, more formally called lymphoid hematopoiesis.
The spleen is almost the sole site of __ during the hepatic phase. lymphopoiesis
What is the 3rd phase of hematopoiesis? Medullary phase (or myeloid phase)
When does the medullary phase begin? Five months
Bone marrow activity increases tremendously during the __ phase. Medullary phase
After __ months, the bone marrow is the primary source of hematopoiesis. 6
CSF stands for __. colony stimulating factors
What do colony stimulating factors do? Cause the cells to proliferate and differentiate into specific kinds of blood cells
Under hypoxic conditions, the __ will produce and secrete erythropoietin to increase the production of red blood cells. Kidney
What is the most common cause of anemia? Iron deficiency
The kind of bone marrow that produces stem cells and all blood cell lines is called __ __ __. Red bone marrow
Megakaryocytes are __ in size and produce __. Large in size and produce platelets.
Macrophages are __ blood cells. White
What color is the bone marrow of 3 year old? Entirely red
At what age does a child's bone marrow start to turn from red to (partially) yellow? 4 years of age. The process ends around 7 years of age.
Adult red marrow is restricted to -- -- -- -- -- -- --. Flat bones, sternum, vertebrae, pelvis, ribs, skull, proximal ends of long bones.
If the body needs to produce more blood cells than the red bone marrow can provide, it can revert to the __ and has __ __ __ as a reserve. The spleen, has yellow marrow-fat as a reserve.
How long do RBCs live? 120 days
What is the normal percentage rate of loss for RBCs in the body per day? 2%
Granulocytes are __ blood cells characterized by the presence of __ in their cytoplasm. White blood cells, granules in their cytoplasm
Adult bone marrow tissue consists of __% marrow and __% fat. 50, 50
In a patient with leukemia, the ratio of __ marrow to fat increases dramatically. red
Phagocytic __ cells in the spleen, liver, and other strategic locations "eat" pathogens as well as eliminating debris from the blood. macrophage
The __ is the storage cite for platelets. spleen
Splenomegaly is __? an enlargement of the spleen
What does splenomegaly indicate? leukemia, lymphomas, RBC problems
Where does differentiation of T cells occur? Thymus
As you get older, the thymus __. Shrinks
Lymph nodes are located __ __ in the body. almost everywhere
B cells are created in the __ __. lymph nodes
What are the 3 main functions of lymph nodes? 1. Form new lymphocytes, 2. process specific antibodies (immunoglobulins), 3. filer debris and bacteria
What is the monophylectic theory? All blood cells are derived from a common stem cell.
What is the polyphyletic theory? There's a separate and distinct stem cell compartment for each blood cell type.
Two major types of stem cells are: noncommitted (also called undifferentiated) and multipotential
What kind of cell is responsible for the stimulation or inhibition of blood cells? cytokine
Another word for white blood cells? Leukocytes
What are the 2 main types of white blood cells myelocytes and lymphocytes
What is leukipoietin? a hypothetical substance presumed to be the humoral means of regulating leukopoiesis.
What is thrombopoietin? A colony-stimulating factor that regulates production of platelets.
What kind of cells platelets come from? Megakaryocytes
Where is erythropoietin produced? The kidney
Created by: IsaacJ