severe gastroenteritis in infants (6mo-2yr)
viral NSP4 protein acts as an enterotoxin
high genetic variability: segmented dsRNA genome and RNA-dependent RNA polymerase
vaccines available
Rhinovirus
picornavirus family
50% of common colds
Adenovirus
multiple strains, enteric, respiratory, ocular infections, systemic infections
severe dz in immunocompromised
Astrovirus
gastroenteritis in infants (less severe than rota), elderly and immunocompromised
Baltimore type II
ssDNA
Baltimore type III
dsRNA
Hendra and Nipah Viruses
newly emerging, animal reservoirs
Coronavirus
2nd most prevalent cause of common colds
SARS
Respiratory syncytial virus
severe lower respiratory dz in infants
very contagious
no vaccine, antiviral therapies avail.
