Question | Answer |
What genus is associated with the spirochetes involved in lyme disease? | Borrelia |
What is another name for Lyme disease? | Lyme borreliosis |
What is the etiological agent for lyme disease? | Borrelia burgdorferi |
What symptoms are associated with the early stage of lyme disease? | headache, fever, myalgia, arthralgia, fatigue, annular erythema at bite site |
What is the annular erythema associated with lyme disease? | A bulls eye rash |
What symptoms are associated with late stages of lyme disease? | arthritis, cardiac and neurological manifestations |
What is the vector for lyme disease? | Ixodes ticks |
How is lyme disease detected in laboratory? | May be cultured, usually via immunoassay |
How soon is antibody detected with lyme disease? | around 10 days |
How soon should a tick be removed to reduce risk of infection? | 36 hours |
What is the etiological agent associated with syphilis? | Treponema pallidum |
What is caused by treponema pallidum? | syphilis |
What symptom is associated with the primary stage of syphilis? | chancre |
What symptoms are associated with the secondary stage of syphilis? | fever, lymphadenopathy, rash |
What symptoms are associated with the tertiary stage of syphilis? | granulomas in the skin, bones, liver, and heart |
What is another name for granulomas? | gummas |
How is syphilis diagnosed in the laboratory? | Darkfield microscopy of chancre
cannot be cultured in vitro
laboratory dx primarily via serology |
What kind of microscopy is used to detect syphilis? | darkfield |
What does RPR stand for? | Rapid plasma regin |
What does a RPR for non-treponemal test do? | detects reagin antibody |
What kind of assay is the non-treponemal RPR? | flocculation assay |
What antigen is used in the flocculation assay for the non-treponemal RPR? | cardiolipin |
The RPR is used in syphilis testing as? | a screener |
What does FTA-ABS stand for? | fluorescent treponemal antibody absorbed |
What does the FTA-ABS do? | It is a treponemal test that detects antibody to T. pallidum |
How does the FTA-ABS work? | Indirect immunofluorescent assay using treponemes as antigen |
The FTA-ABS is used in syphilis testing as? | Confirmatory |