Question | Answer |
Pupura | abnormal bleeding. |
Wiskott-Aldrch syndrome | Smallest platelets seen |
May-Hegglin anomaly | large platelets |
Alports syndrome (hereditary) | Giant platelets and thrombocytopenia |
Bernard-Soulier syndrome | largest platelets seen . Autosomal bleeding disorder, missing platelets glycoproteins |
Increased utilization of platelets | intravascular coagulation,vascular injury, DIC, Trauma |
Severe Liver disease | Decreased fibrinogen levels,Prolonged PT |
Hemophilia A | Inherited. Factor 8 functionally inactive. Impairs coagulation ability. Male sex linked. |
VonWillebrand Disease | Acquired. Associated with Lupus.prolonged bleeding times. |
DIC | complication or result of other diseases. d dimer, pt, aptt all increased |
Antithrombin III | Inhibits thrombin. Protease inhibitor. |
Heparin Cofactor | inhibits thrombin. |
Protein C | Major blood coagulation regulatory . Vit k dependent |
APTT Activated Partial Thromboplastin Time | time required to make thrombin and fibrin polymers. Normal less then 35 sec
Evulates XII,XI,VII,X,V,II and II using intrinsic |
PT Prothrombin Time | Time required to generate thrombin and fibrin using extrinsic. Thromboplastin and Ca2+. Evulates VII,X,V,II or I |
INR International Normal Ratio | Standardize the difference in sensitivity of thromboplastin reagents and the effects on PT assays |
INR Ratio | INR= (PT/mean normal pro time) |