Question | Answer |
Blue Top | Sodium Citrate. Removes calcium by precipitating it. |
Green Top | Heparin. Only anticoagulant that does not inactivate or consume calcium. Prevents blood clotting thrombin. |
Purple Top | EDTA. Removes calcium through chelatin. |
Watson and Crick | Discovered DNA |
Hematopoiesis | Blood cells are produced, differentiated and developed |
Origin of blood cells | mesoderm of embryo |
What are the phases of fetal hematopoiesis | mesoblastic, Hepatic and myeloid phase |
Mesoblastic phase | Yolk Sack. Produce pluripotent cells. portland, gower I and II |
Hepatic phase | 4-5th week gestation. occurs in liver and rbc produced |
Meyloid phase | production of pluripotential cells. G-CFU, E-CFU,GM-CFU,MM-CRU |
Progenitor cells | Will form into one distinct cell line |
Blood cell migration path | capillary sinuses of the bone marrow->sinus spaces-->into circulation. |
What is a interleukin | involved with development and growth of B and T lymphs |
Erythropoietin | produced in the kidneys, secreted by the liver |
Polycythemia | increased rbc concentration. |
Reticulocyte | in bone marrow for 2.5 days. In blood for 1 day. |
Developmental stages RBC | CFU-GEMM,BFU-E, CFU-E,Pronomoblast,Prorubicyte,Rubicyte,Metarubicyte,Reticulocyte |
Reticulocyte | Polychromatic Eryocyte |
Metarubicyte | Orthochromatic |
Stain for Retics | new methylene blue. precipitates RNA into a mesh on cell |
Normal concentration for hemoglobin | 34 g/dl |
Heme is from | Porphrin |
Ferritin is stored | liver |
What is a shift to the left | increased affinity to oxygen binding |
Globin chains contain | 2 alpha, 2 gamma chains made in the liver |
Heinz bodies | denaturation and precipitation of hemoglobin. can cause cyanosis |
Leve-Jennings charts displays | control vs time |
sequence of fetal blood cell devolopment | yolk sac, liver, red marrow |
Antiocoagulant prevents clotting by inhibiting thrombin | Heparin |
Hematopoiesis stops in the liver | 1-2 weeks after birth |
Thrombopoietin | Stimulates formation of megakaroblast to megakaryocytes |
Leukopoietin | stimulates white cell formation |