Question | Answer |
Elution | Removal of antibody coating on RBC |
What is papin or ficin used for? | eliminate or enhance antibody activity. Eliminates Fya,Fyb,S,M and N |
What is the major cause fo transfusion associated fatalities? | clerical error resulting in incorrect ABO groupings |
How long does donor and recipient samples must be kept | 7 days |
whole blood units are | 63 ml anticoagulant to 450 ml blood |
The total volume of packed red blood cells is | 200-225ml
300-330 ml with additive solution |
a unit of PRBC raises the hematocrit | 3-5% |
AS-1 and AS-3 extend the unit life up to | 42 days |
CPDA extends the unit life up to | 35 days |
Freezing of units is good up to | 10 years. Thawed 24 hours. |
WBC in a unit may cause | Febrile non hemolytic rxn and transfusion related immune sppression |
Irraiated units last for | 21-28 days |
Platelet concentration is done in | 2 parts. Soft spin followed by a hard spin. |
When are platelet transfusions needed? | Decreased plt production. Increased platelet destruction (DIC) and massive transfusions. |
Each unit of platelets should | increase the platelet count by 5,000 to 10,000 |
FFP is prepaired from whole blood and must be frozen with in | 6 hours of collection |
FFP contains | proteins,carbs an lipids |
FFP is transfused to replace | coagulation proteins. liver failure patients,DIC,Vit K deficiency, overdoe of coagulation meds, massive transfusions |
FFP must be | ABO type specific |
Type O can receive | any FFP. universal recipient |
FFP once thawed is good for | 5 days. 1-6 degrees. |
Cryoprecipitate antihemophilic factor contains | Factor VIII (hemophilia A) , fibrinogen,Von Willebrand factor, and factor XIII, factor IX (hemophilia B) |
Cryo is used for | fibrinogen replacement 150 mg. Previously used for factor VIII |
Cryo is good for | 1 year when stored at -18 or colder. Good for 24 hours 1-6 degrees thawed. |
Granulocyte Pheresis | given to patients who are neutropenic, infection unresponsive to antibiotics,bone marrow failure patients |