Term | Definition |
genetics | the study of transmission of inherited disease |
hematopoiesis | the formation and development of blood cells; chiefly in the bone marrow |
extramedullary hematopoiesis | the formation and development of blood cells outside the bone marrow in sites such as the liver and spleen |
Athansius Kircher | 1657. Saw a microbe through a microscope and described them as 'worms' in the blood. Early Scientist/Jesuit Scholar. |
Antonie van Leeuwenhoek | 1674. aka "Father of Microbiology". Gave an account of RBC's. |
Guilio Bizzozero | 1800's. Discovered platelets and called them 'petite plaques. Credited for platelets role in coagulation and the discovery of H.pylori. Was a Medical Researcher and Italian Physician. |
James Homer Wright | 1902. Developed the Wright Stain to be able to examine blood differently through a microscope. Was a Pathologist. |
Describe the Functions of Hematology | Describe the Functions of Hematology |
plasma | the straw-colored fluid component of blood |
serum | straw-colored fluid that is present after blood clots |
Embryonic Hematopoiesis | makes erythroblasts in the mesoderm of the embryo |
Fetal-Mesoblastic Phase | Occurs in the fetus. 'yolk sac phase'. creates Primary Plueripotential cells. Is characterized by fetal hemoglobin. |
Fetal-Hepatic Phase | Occurs 4-5 weeks of gestation. Occurs in the liver where erythroblasts develop in to non-nucleated RBC's. Remains the primary source of hematopoiesis until 1-2 weeks after birth. {Midfetal life- secondary hematopoeitic organs are developed} |
Medullary Phase | Hematopoeisis occurs in the bone marrow. Liver production is diminished. Production of stem cells for all 4 stem lines. |
After Birth | Hematopoiesis stops in the liver 1-2 weeks after. Bone Marrow is the only site for production of erythrocyte, granulocytes, monocytes, platelets and B lymphocytes. |
Bone Marrow | One of the largest organs in the body. Tissue found in the cavities of the bones. Comes in the form of yellow and red. Function: Hematopoiesis. |
Yellow Bone Marrow | Mostly fat. Doesn't have a role in hematopoiesis. |
Red Bone Marrow | Hematopoietically active. Network of capillary and fibrous connective tissue. Production of leukocytes, erythrocytes, and thrombocytes. |
Hematopoietic Cell Development (aka. Monophyletic Theory) | all blood cells are derived from one stem cell line. |
Stages in the Monophyletic Theory | Primitive, multipotential cells; intermediate cells; and mature cells. |
Monophyletic Theory- Primitive, Multipotential Cells | Occurs during the mesoblastic stage. Forms stem cell. Most immature cells. Able to differentiate into all blood cell lines when stimulated by chemical stimulus. 1% of bone marrow population. |