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Hematology Exam #1

CLLS 2015

genetics the study of transmission of inherited disease
hematopoiesis the formation and development of blood cells; chiefly in the bone marrow
extramedullary hematopoiesis the formation and development of blood cells outside the bone marrow in sites such as the liver and spleen
Athansius Kircher 1657. Saw a microbe through a microscope and described them as 'worms' in the blood. Early Scientist/Jesuit Scholar.
Antonie van Leeuwenhoek 1674. aka "Father of Microbiology". Gave an account of RBC's.
Guilio Bizzozero 1800's. Discovered platelets and called them 'petite plaques. Credited for platelets role in coagulation and the discovery of H.pylori. Was a Medical Researcher and Italian Physician.
James Homer Wright 1902. Developed the Wright Stain to be able to examine blood differently through a microscope. Was a Pathologist.
Describe the Functions of Hematology Describe the Functions of Hematology
plasma the straw-colored fluid component of blood
serum straw-colored fluid that is present after blood clots
Embryonic Hematopoiesis makes erythroblasts in the mesoderm of the embryo
Fetal-Mesoblastic Phase Occurs in the fetus. 'yolk sac phase'. creates Primary Plueripotential cells. Is characterized by fetal hemoglobin.
Fetal-Hepatic Phase Occurs 4-5 weeks of gestation. Occurs in the liver where erythroblasts develop in to non-nucleated RBC's. Remains the primary source of hematopoiesis until 1-2 weeks after birth. {Midfetal life- secondary hematopoeitic organs are developed}
Medullary Phase Hematopoeisis occurs in the bone marrow. Liver production is diminished. Production of stem cells for all 4 stem lines.
After Birth Hematopoiesis stops in the liver 1-2 weeks after. Bone Marrow is the only site for production of erythrocyte, granulocytes, monocytes, platelets and B lymphocytes.
Bone Marrow One of the largest organs in the body. Tissue found in the cavities of the bones. Comes in the form of yellow and red. Function: Hematopoiesis.
Yellow Bone Marrow Mostly fat. Doesn't have a role in hematopoiesis.
Red Bone Marrow Hematopoietically active. Network of capillary and fibrous connective tissue. Production of leukocytes, erythrocytes, and thrombocytes.
Hematopoietic Cell Development (aka. Monophyletic Theory) all blood cells are derived from one stem cell line.
Stages in the Monophyletic Theory Primitive, multipotential cells; intermediate cells; and mature cells.
Monophyletic Theory- Primitive, Multipotential Cells Occurs during the mesoblastic stage. Forms stem cell. Most immature cells. Able to differentiate into all blood cell lines when stimulated by chemical stimulus. 1% of bone marrow population.
Created by: acsideris