Question | Answer |
Erythrocytes are __ __ cells. | Red blood cells |
Normal RBCs developing in bone marrow are called __. | Normoblasts |
What is a megaloblast? | An unusually large erythroblast. |
What does the presence of megaloblasts indicate? | Vitamin B12 deficiency and/or folic acid deficiency |
The maturation of normoblasts into true erythrocytes is controled by a __ __ __. | feedback loop mechanism |
An erythroblast is __? (Define it) | an RBC that retains a nucleus and the precursor of an erythrocyte. |
The presence of megaloblasts is called? | Megaloblastic anemia |
What are the criteria used in identifying erythroid precursors? | 1. Good stain and smear 2. Use of Wright's stain 3. Determine stage of maturation 4. Examine cell nucleus, cytoplasm, and size. |
The first stage in the maturation sequence of RBCs is called a __ or a __. | Rubriblast or a pronormoblast |
The 2nd stage in the maturation sequence of RBCs is called a __ or a __. | Prorubricyte or a basophilic normoblast |
The 3rd stage in the maturation sequence of RBCs is called a __ or a __. | Rubricyte or a polychromatic normoblast |
The 4th stage in the maturation sequence of RBCs is called a __ or a __. | Metarubricyte or an orthochromic normoblast |
The 5th stage in the maturation sequence of RBCs is called a __ or a __. | Reticulocyte or a polychromatophilc rbc |
The 6th stage in the maturation sequence of RBCs is called a __. | Mature erythrocyte |
What type of stain do you use to spot a reticulocyte? | New methylene blue |
What part of the cells gives a retic stained with new methylene blue the appearance of blue dots? | Reticulum |
New methylene blue is what kind of stain? | Supravital |
Retics stay how many days in the bone marrow? | 2-3 |
How long do retics circulate in our blood stream? | 1 day |
For every 100 erythroctyes, there are how many retics? | 1 |
Percentage-wise, what is the normal range of reticulocytes in an adult human body? | 0.5 - 1.5% |
What is the last stage in the maturation of an RBC before it becomes an erythrocyte? | Reticulocyte |
How long does it take a stem cell to develop into a full erythrocyte? | 4 - 5 days |
What is the average diameter of a healthy erythrocyte? | 7 um |
What is the main function of an erythrocyte? | To deliver oxygen throughout the body |
What percentage of a mature erythrocyte is made of hgb (hemoglobin)? | 90% |
Erythropoietin (the hormone that controls the rate of erythrocyte production) increases under what 3 factors? | 1. hemorrhage, 2. increased RBC destruction, 3. other factors reducing oxygen tension |
What part of the kidney produces erythropoietin? | Peritubular interstitial cells |
Erythropoietin acts on the __ __. | Bone marrow |
What does it mean when a patient has aplasia? | Their body isn't responding to erythropoietin. |
Apoptosis is __ __ __. | Programmed cell death |
Shift retics have __ __ due to early release. | more RNA |
Iron is used in the synthesis of __. | hemoglobin |
The __ __ __ is a system of fixed macrophages located all over the body, especially the spleen. | reticuloendothelial system (RES) |
As erythrocytes age, their shape becomes more __. | spherical |
As erythrocytes age, they accumulate __ due to decreased enzyme activity. | methg, or methemoglobin |
Learn the chart about Extravascular hemolysis!! | |