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Pain Transmission
Spinal Transmission
Question | Answer |
---|---|
What is the definition of Endogenous Opiods? | Opiate-like transmitter substances having INHIBITORY effects on C-fiber Pain |
Name 2 types of Endogenous Opiods. | Endorphins, Enkephalins |
Where are Endogenous Opiods located? | Brain, Spinal Cord |
What is the function of Gate Control Theory? | BLOCK Excrutiating/Redundant Pain |
What is "Closed Gate" ? | A-fiber dominates over C-fiber Pain |
How does "Closed Gate" Inhibition work? | A-fiber exerts PREsynaptic Inhibition at C-fiber synapses via Enkephalin-releasing Interneurons |
What are some examples of Closed Gate Inhibition? | Counter Irritation, Acupuncture |
What is "Open Gate"? | dominence of C-fiber activity can override A-fiber Inhibition --> prolonged, high intensity Pain |
What are some example of "Open Gate" pain? | Headache, Muscle/Joint Pain, Tumors |
What is the significance of Open Gate Pain? | forces Action Evasion --> opportunity to Heal |
How does descending Inhibition work? | Neurons from Cerebrum can act through Enkephalin-releasing fibers at Spinal Gate |
What are 2 examples of Descending Inhibition? | 1. Placebo effect; 2. Combat Anesthesia |
Where is the Enkephalin neuron located? | between the descending fiber and C-fiber Inhibitory site |