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Pain Transmission

Spinal Transmission

QuestionAnswer
What is the definition of Endogenous Opiods? Opiate-like transmitter substances having INHIBITORY effects on C-fiber Pain
Name 2 types of Endogenous Opiods. Endorphins, Enkephalins
Where are Endogenous Opiods located? Brain, Spinal Cord
What is the function of Gate Control Theory? BLOCK Excrutiating/Redundant Pain
What is "Closed Gate" ? A-fiber dominates over C-fiber Pain
How does "Closed Gate" Inhibition work? A-fiber exerts PREsynaptic Inhibition at C-fiber synapses via Enkephalin-releasing Interneurons
What are some examples of Closed Gate Inhibition? Counter Irritation, Acupuncture
What is "Open Gate"? dominence of C-fiber activity can override A-fiber Inhibition --> prolonged, high intensity Pain
What are some example of "Open Gate" pain? Headache, Muscle/Joint Pain, Tumors
What is the significance of Open Gate Pain? forces Action Evasion --> opportunity to Heal
How does descending Inhibition work? Neurons from Cerebrum can act through Enkephalin-releasing fibers at Spinal Gate
What are 2 examples of Descending Inhibition? 1. Placebo effect; 2. Combat Anesthesia
Where is the Enkephalin neuron located? between the descending fiber and C-fiber Inhibitory site
Created by: Kristel