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Action Potentials
Generation
Question | Answer |
---|---|
What is the definition of Threshold Stimulation? | the minimum DEPOLARIZATION required to trigger a Na+ permeability change --> AP |
What is the definitions of Subthreshold? | Insufficient DEPOLARIAZATION for a response |
T/F The lower the amplitude of an AP the less likely it is to reach the synapse. | F. All-or-None Principle - AP attains FULL amplitude (30mv at 1ms) or it does not occur |
What is Hyperpolarization? | MORE negative RP --> decreased membrane excitability |
What are some of the causes of Hyperpolarization? | 1. INTERFERENCE with Na+ INFLUX; 2. INCREASED Extracellular Ca++ |
What medicine causes Hyperpolarization and what is its function? | Lidocaine - interference with Na+ INFLUX - anesthesia |
What is Depolarization? | LESS negative RP --> INCREASED membrane Excitability |
What are some causes of Depolarization? | 1. ENHANCEMENT of Na+ INFLUX; 2. DECREASED Extracellular Ca++ |
What is Paresthesia? | Increased membrane permeability |
What is a side effect of Paresthesia? | Abnormal Sensation, Hallucination, Hearing Things, Schizo |