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listado de anticoagulantes

flujo sanguíneo impide que los coagulantes se concentren
heparina cofactor de antitrombina III; elimina la trombina, aIX, aX, aXI, aXII; sintetizado por mastocitos pericapilares
plasmina disuelve la fibrina, induce a fibrinólisis
t-Pa activa la plasmina y la fibrinólisis
NO efecto antiadhesivo y vasodilatador; estimulado por protrombina, bradicinina, serotonina
prostaciclinas inhibe la función plaquetaria; vienen estimuladas por el hiperflujo, fricción y AINE
adenosina inhibe la función plaquetaria; procede del ATP y ADP
HODE inhibe función plaquetaria
antitrombina III elimina la trombina y aIX, aX, aXI, aXII; sintetizado por mastocitos pericapilares
trombomodulina forma complejos que eliminan la trombina y elementos procoagulantes
prot C activa la trombomodulina; viene regulada por la presencia de K y Ca; inhibe PAI (factor inhibidor de plasminógeno)que impide la fibrinólisis
prot S activa la prot C uniéndola a la mb plasmática; necesita K cofactor de IVFT
IVFT inhibe el factor tisular, X
prot Z inhibe a X; depende de la presencia de K
anexinas impide la activación de complejos pro-coagulantes como el t-PA
α2-macroglobulina inhibidor de proteasas; puede inhibir la trombina, la plasmina, la calicreína y la proteína C activada, entre otras
Created by: pablosbartrina