Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Path BRS ch. 3
hemodynamic dysfunction
| Question | Answer |
|---|---|
| heart failure cells | hemosiderin laden macrophages from capillary rupture caused by left sided heart failure and pulmonary congestion |
| what do platelets release after adhesion? | ADP, histamine, serotonins, PDGF |
| how do platelets make thromboxane A2, and what does thromboxane A2 (TxA2) do? | cyclooxygenase pathway from arachidonic acid. potent vasoconstrictor and platelet aggregant |
| PGI2 - who makes it, and what does it do? | made by endothelial cells, antagonistic to platelet TxA2. |
| what activates antithrombin? and what does it do? | heparin. endothelial cells release heparin-like molecules |
| what molecules promote aggregation? | ADP thrombin, TxA2, collagen, epinephrine, PAF |
| what do endothelial cells do to prevent aggregation? | produce heparin-like molecules, tissue plasminogen activator (TPA), degrades ADP, clears thrombin, activates protein c (APC) which cleaves Va and VIIIa. synthesizes protein S (APC cofactor) and synthesizes PGI2 and NO |
| what does XIIa do? | activates intrinsic pathway, activates prokallikrein to kallikrein, which in turn activates HMWK to bradykinin, and plasminogen to plasmin. Plasmin degrades fibrin, and activates complement |
| what does APC (active protein c) cleave? | Va and VIIIa |
| factor V leiden | altered cleavage site on facto V normally recognized by APC |
| prothrombin 20210A transition | most common hereditary thrombophilia. mutation in prothrombin gene - elevated plasma prothrombin levels. |
| anticardiolipin antibody | associated with SLE, gives false positive tests for syphilis |
| "lupus anticoagulant" | antiphospholipid antibody that increases thrombosis. It actually shows an in vitro artifact prolonged PTT time. It is often associated with SLE |
| HIT syndrome | heparin induced thrombocytopenia. Antibodies against heparin-platelet factor 4 complex. |
| what causes mural thrombi of left atrium and left ventricle | atrium: mitral stenosis, ventricle: myocardial infarction |
| what is a paradoxical embolus? | venous embolus that went to arterial side by way of right-to-left shunt (ASD, or foramen ovale) |
| amniotic fluid in the blood... | means embolus, and DIC |
| what is anasarca | generalized edema |
| most important anatomic finding in shock | acute tubular necrosis |
Created by:
iplayguitar
Popular Physiology sets