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Phys4 GI Lect2

Phys4 Neural control of GI function

Which nervous system is responsible for carrying the visceral afferents back to the brain? PNS
3 possible pathways of a sympatheic efferent signal 1.Synapse at its same spinal level on the sympathetic chain. 2.Travel up & down the chain and synapse. 3.Bypass the chain and synapse elsewhere (this is the case for GI SNS).
Where do the SNS GI Preganglionic neurons synapse? Synapse on either the: 1.Celiac Ganglia. 2.Superior Messenteric Ganglia. 3.Inferior Messenteric Ganglia. **Also sometimes directly on the target organ itself.
What do sympathetic afferents carry back to the brain? PAIN
PNS affect on GI 1.Relaxes sphincters. 2.Inc motility & tone. 3.Inc secretion. **Via ACh->M3
SNS affect on GI 1.Contract sphincters (a1). 2.Dec tone & motility. 3.Dec secretions. **Use NE on B2/A2 and A1
Where will NE acting on A2 occur in the GI? they will be on the PREsynaptic nerve, serve an inhibitory function.
Can Vagal nerve stimulation cause muscle relaxation of the GI muscle? YES, they sometimes synapse onto INHIBITORY neurons.
Layers of the Duodenum 1.Intestinal Villi w/ epithelial lining. 2.Lamina propria (will find glands & vessels here). 3.Muscularis Mucosa ( 4.Submucosa. 5.Muscularis Externa (Very important for motility. 6.Serosa.
How are the muscle fiber arranged in the muscularis externa 1.Outer longitudinal muscle layer (along the length of the tube). 2.Inner circular muscle layer(along the circumfrence).
Names and locations of the 2 main Enteric NS ganglion w/in the gut tube 1.Myenteric (Aurbach's) Plexus: Located b/w the longitudinal & Circular muscle layers, runs from proximal esophagus to rectum. 2.Submucosal Plexus: Located b/w the submucosa & circular muscle layers, only in large & small intestine.
Primary function of Myenteric Plexus Movement & Motility.
Primary function of Submucosal Plexus Blood flow and Secretion
How would you classify the neuronal signals leaving the enteric nerves? POST-ganglionic: 1.Post-gang PNS. 2.Post-Post-gang SNS. 3.Post Enteric
Do they PNS and SNS synapse primarily on the Enteric ganglia within the GI walls? Yes, SNS can also synapse directly onto target organs. **Just remember it is Pre-gang PNS and Post-gang SNS synapsing on the enteric ganglia
Potential synapses of afferent GI sensory neurons 1.Synapse on enteric plexus (short pathway). 2.Travel to prevertebral ganglia (long pathway SNS). 3.Travel to brain & spinal cord (long pathway).
Example of a hormone that is also a neurotransmitter CCK
Classic GI excitatory neurotransmitters are 1.ACh. 2.Sustance P family (neurokinins or tachykinins).
Classic Inhibitory GI neurotransmitters are 1.VIP (found exclusively w/in the nerves, inhibits smooth mucle). 2.NO.
Long reflexes of the ANS Reflexes with: (typically VAGO-VAGAL reflex). afferent arm traveling to CNS. efferent arm travelling back to the gut from the CNS.
Short reflexes of the ANS (local or intramural reflexes) take place ENTIRELY within the gut wall. **No travel to and from CNS, Efferent info comes directly from Enteric NS.
Created by: WeeG



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