Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Phys3 K+ balance

QuestionAnswer
Where does Medullary K+ recycling occur? Long looped juxtaglomerular nephrons.
Steps of medullary K+ recycling 1.K+ secreted into thin descending limb. 2.K+ is reabsorbed by both ascending limbs & deposits in the interstitium. 3.K+ is reabsorbed from medullary CDs and deposits in interstitium. 4.K+ becomes trapped in medullar interstitium.
What is the net movement of K+ in the loop of Henle? REABSORPTION. ascending loops reabsorb more than descending loops secrete.
Where is interstitial K+ highest? At the papilla.
Why is the high medullary [K+] created from K+ recycling important? During high K+ intake, there is a lot of secretion into the tubule lumen (as high as 200mOsm). With a high interstitial [K+], there will be less passive diffusion out of the tubule lumen.
What type of reabsorption of K+ occurs in the PT? paracellular.
How is K+ reabsorbed in the thick ascending limb? Via NKCC (Na/2CL/K symporters) which are the target of loop diuretics.
How do principle cells effect [K+] They secrete K+ through channels on the apical membrane into the tubule lumen.
How do loop diuretics affecting the PT, Loop of Henle, and DCT affect [K+] 1.Inhibit K reabsorption. 2.Inc K secretion. **INCREASE K+ EXCRETION.
Types of K+ channels on apical principal cell membrane and how they respond to [K+] 2 types: ROMK & BK. 1.Low [K+]: ROMK sequestered, BK closed. 2.Normal [K+]: ROMK open, BK closed. 3.High [K+]: Both are OPEN. **respond to K+ excretory rate.
When are principle BK channels on the apical membrane open? Hyperkalemia.
What occurs on the apicl membrane of the CDs to affect [K+] REASBSORPTION through H/K exchangers.
Factors causing Inc K+ secretion in distal nephron 1.High K diet. 2.Non-Chloride anions in distal nephron. 3.High flow rate in distal nephron. 4.High Na delivery in distal nephron. 5.High plasma K. **Hyperkalemia will trigger aldosterone.
Metabolic acidosis' affect on K+ H+ wants to move out of the plasma and into the cell to restore pH. This causes K+ to move into plasma: HYPERKALEMIA.
Metabolic alkalosis' affect on K+ H+ wants to move into the plasma to restore pH. Therefore K+ moves out into the cells causing: HYPOKALEMIA
Created by: WeeG