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Phys3 K+ balance

Where does Medullary K+ recycling occur? Long looped juxtaglomerular nephrons.
Steps of medullary K+ recycling 1.K+ secreted into thin descending limb. 2.K+ is reabsorbed by both ascending limbs & deposits in the interstitium. 3.K+ is reabsorbed from medullary CDs and deposits in interstitium. 4.K+ becomes trapped in medullar interstitium.
What is the net movement of K+ in the loop of Henle? REABSORPTION. ascending loops reabsorb more than descending loops secrete.
Where is interstitial K+ highest? At the papilla.
Why is the high medullary [K+] created from K+ recycling important? During high K+ intake, there is a lot of secretion into the tubule lumen (as high as 200mOsm). With a high interstitial [K+], there will be less passive diffusion out of the tubule lumen.
What type of reabsorption of K+ occurs in the PT? paracellular.
How is K+ reabsorbed in the thick ascending limb? Via NKCC (Na/2CL/K symporters) which are the target of loop diuretics.
How do principle cells effect [K+] They secrete K+ through channels on the apical membrane into the tubule lumen.
How do loop diuretics affecting the PT, Loop of Henle, and DCT affect [K+] 1.Inhibit K reabsorption. 2.Inc K secretion. **INCREASE K+ EXCRETION.
Types of K+ channels on apical principal cell membrane and how they respond to [K+] 2 types: ROMK & BK. 1.Low [K+]: ROMK sequestered, BK closed. 2.Normal [K+]: ROMK open, BK closed. 3.High [K+]: Both are OPEN. **respond to K+ excretory rate.
When are principle BK channels on the apical membrane open? Hyperkalemia.
What occurs on the apicl membrane of the CDs to affect [K+] REASBSORPTION through H/K exchangers.
Factors causing Inc K+ secretion in distal nephron 1.High K diet. 2.Non-Chloride anions in distal nephron. 3.High flow rate in distal nephron. 4.High Na delivery in distal nephron. 5.High plasma K. **Hyperkalemia will trigger aldosterone.
Metabolic acidosis' affect on K+ H+ wants to move out of the plasma and into the cell to restore pH. This causes K+ to move into plasma: HYPERKALEMIA.
Metabolic alkalosis' affect on K+ H+ wants to move into the plasma to restore pH. Therefore K+ moves out into the cells causing: HYPOKALEMIA
Created by: WeeG



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