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Phys Lect 18

Pre and Post synaptic Neurotransmitters of the Parasympathetic NS ACh is used at both of the synapses
Pre and Post synaptic Neurotransmitters of the sympathetic NS ACh is the Presynaptic Neurotransmitter in the sympathetic chain. Norepi is the neurotransmitter used by the post synaptic neuron.
Parasympathetic ACh receptors 1.Nicotinic: Located in the ganglia on Postsynaptic dendrites. 2.Muscarinic: Located in effector organ.
Main N receptor Antagonist (Anticholinergic) Hexamethonium. Blocks parasympathetics all over the body at the ganglion before the postsynaptic neuron.
Main M receptor Antagonist (Anticholinergic) Atropine. Blocks parasympathetics at the end organ so therefore can be administered locally.
Agonists that mimic ACh Cholinergic 1.Nicotine act like ACh for N receptors. 2.Muscarine act like ACh for M receptors
Sympathetic Receptors 1.Nicotinic: On the postsynaptic dentrites in the sympathetic chain or at a ganglion (**Also blocked by Hexamethonium). 2.Adrenergic: on target organ, binds Epi/Norepi.
Chromaffin cells Located in the adrenal Medulla. Have ACh Nicotinic receptors on them and receive presynaptic sympathetic. **These cells are responsible for Epi/Norepi mass release into the blood stream (release PRIMARILY EPI).
Where will Norepi be released from? Epi? Norepi: Postganglionic neurons. Epi:Adrenal Medulla
Alpha Adrenergic receptors Agonist: 1.Norepi > Epi. 2.Phenylephrine. Antagonists: 1.Phentolamine
Beta Adrenergic receptors 1.B1 agonists: Epi=Norepi. 2.B2 agonists: Epi >>> Norepi
Antagonist for all 3 Beta adrenergic receptors Propanolol
Where are Beta3 Adrenergic receptors found? Adipose cytes: encourage lipolysis in the presence of agonist for the creation of energy for bodily use.
Created by: WeeG



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