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Phys Lect 3

QuestionAnswer
Resting membrane potential of all cells -60 to -90 mV **This polarization aids in absorption/secretion and excitability
Ion movement depends on: 1.Concentration gradient. 2.Electrical gradient.
What is the net ion movement when the concentration gradient and electrical gradient are equal in magnitude but opposite in direction? NO NET MOVEMENT!!
Will natural ion flow down its concentration gradient alter membrane (electrical) potential? Yes, slowly it will approach the Nernst potential or equilibrium where there will be NO NET MOVEMENT
Driving force Concentration gradient + Electrical gradient
Nernst Potential (Equilibrium) Potential at which there is zero driving force for a given ion.
Equilibrium potential for K+ -88mV. Which means there is an outward driving force until the inside of the cell reaches -88mV. **At this point there is no more net driving force or movement b/c it is at equilibrium. **Most cells need to get more negative to reach this point
Equilibrium potential for Na+ +70mV. which means there is an inward driving force until the inside of the cell reaches +70mV. **At this point there is no more net driving force or movement b/c it is at equilibrium.
Equilibrium potential for Ca2+ +122mV. which means there is an inward driving force until the inside of the cell reaches +122mV. **At this point there is no more net driving force or movement b/c it is at equilibrium.
Intra/extracellular concentrations of K+ Intra:140. Extra:5
Intra/extracellular concentrations of Na+ Intra:10. Extra:140
Intra/extracellular concentrations of Ca2+ Intra:0.0001. Extra:1
Intra/extracellular concentrations of Cl- Intra:20 Extra:116
Equilibrium potential for Cl- -47mV. Which means there is an inward driving force until the inside of the cell reaches -47mV. **At this point there is no more net driving force or movement b/c it is at equilibrium.
What happens when a membrane becomes selectively permeable to an ion? the membrane potential becomes that ion's nernst potential.
With the normal intra/extracellular concentrations of K+ and the cell's membrane at the normal milivoltage, how will the K+ move? What will happen to the membrane potential? They will move outward until there is an internal membrane potential of -88mV. The membrane potential will become MORE NEGATIVE going from -70mV to -88mV
Created by: WeeG
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