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Phys Lect 2

Key functions of Cell Membrane Keeps essential cell proteins within the cell. Also, b/c it is selectively permeable, it allows for movement of: 1.substrates. 2.metabolites (ex: glucose). 3.signaling molecules (ex: Ca2+).
Main requirement of BULK FLOW molecule movement? Driving pressure. **EX: Inpiration: expansion of the lungs causes a lower pressure within the lungs than outside, therefore the driving pressure moves air from the atmosphere into the lungs
Factors effecting rate of diffusion 1.Concentration gradient. 2.Area available for diffusion (More A = Inc rate). 3.Permeability Coefficient (lipid solubility: size and charge)
On a diffusion Rate graph, a line with the same concentration gradient will have a lower slope if: The Permeability coefficient or the Area of diffusion is lowered.
Is Facilitated diffusion Saturable? YES. Once all proteins are occupied, the rate of diffusion will no longer increase no matter the concentration increase.
One method of controlling ion movement across membranes Ligand or Voltage gated channels.
3 main ways molecules move in physiological systems 1.Simple diffusion. 2.Facilitated diffusion (requires a membrane-bound protein channel/gate). 3.Active Transport.
Graphical depiction for simple diffusion? Linearly increasing
Graphical depiction for facilitated diffusion? Increases until a certain point and then levels off b/c all the protein channels are occupied: SATURATED
What is secondary active transport? ATP is NOT directly used: the movement of one molecule across its [con] gradient via symporter or antiporter. **It uses the displacement of the molecules from the Na/K ATPase to drive the symporter/antiporter.
How do Cl- and H+ reach the stomach lumen from the parietal cell? 1.Cl- comes enters parietal cell via chlorid-bicarbonate antiporter (secondary active transport) and then enters the stomach lumen via Cl- channel (facilitated diffusion). 2.H+ is exported into the stomach lumen through a H+/K+ ATPase (Active transport)
What does Omeprazole do? Inhibits H+/K+ ATPase causing a decrease in stomach acid production. **Treats HEART BURN**
Created by: WeeG



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