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Biochem-Cosub etc
Med’11 Biochemistry Enzymes - Cosubstrates, Prosthetic Groups, &Vitamins
| Question | Answer |
|---|---|
| NADH (& NADPH) | Nicotinamide adenine dinucleotide Precursor: Niacin Defic: Pellagra Role: Redox involving 2-e transfer Enz: Dehydrogenase |
| FAD | Flavin adenine dinucleotide Precursor: riboflavin B2 Defic: growth retardation Role: redox involving 1- and 2-e transfer Enz: flavoenzymes |
| CoA | Coenzyme A Precursor: pantothenate B3 Defic: dermatitis in chicks Role: acyl transfer Enz: 100s of enz |
| TPP | Thiamine Pyrophosphate Precursor: Thiamine B1 Defic: beriberi Role: transfer of 2-C fragment containing carbonyl Enz: some carboxylases |
| PLP | Pyroxidal Phosphate Precursor: pyroxidal, pyroxine, pyroximine B6 Defic: dermatitis in rats Role: transfer of groups to and from A.A. Enz: transaminase |
| Biotin | Biotin Precursor: Biotin Defic: dermatitis in humans Role: carboxyl grp transfer & ATP dependent carboxylation Enz: some carboxylases |
| Tetrahydrofolate | Tetrahydrofolate Precursor: folic acid Defic: anemia, spina befida Role: 1-C transfer Enz: dihydrofolate reductase & others |
| Cobalamin | Cobalamin Precursor: methylcobalamin, adenosylcobalamin Defic: pernicous anemia Role: intermolecular rearrangement, methyl transfer Enz: methylmalonyl-coA mutase; homocysteine methyltransferase |
| Lipoamide | Lipoamide Precursor: lipoic acid Defic: NONESSENTIAL Role: acyl transfer Enz:dihydrolipoamide; acyltransferase |
| Vitamin K | Deficiency: blood clotting disorder Role: carboxylation of Glu Enz: vitamin K-dependent carboxylase |
| Ubquinone | AKA: Coenzyme Q Role: electron transfer Enz: mitochondrial enzyme |
| Vitamin A | Role: Vision Solubility: Lipid Deficiency: Night blindness |
| Vitamin C | Role: Antioxidant Solubility: Water Deficiency: Scurvy |
| Vitamin D | Role: Gene expression Solubility: Lipid Deficiency: Rickets |
| Vitamin E | Role: Antioxidant Solubility: Lipid Deficiency: Fragile blood cells |
Created by:
Salma O
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