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lecture 27 gruchalla

medicines notorious for causing Stevens-Johnson syndrome anticonvulsants, NSAIDs, sulfonamides
bioactivation/hapten hypothesis immunogens are formed usually after metabolism of a drug or conjugation of a drug hapten to proteins in the body (ex. PCN, Sulfa)
when desensitization is performed in pts whom IgE Abs to a particular drug are known or are presumed to exist and NO ALTERNATIVE drug is available
in vitro test for mast cell degraunulations serum tryptase is the selective marker; may not be elevated in well-hydrated normotensive pts. peak levels are 2 hrs after anaphylaxis
Created by: sirprakes