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TCA cycle

Per Westericks objectives

QuestionAnswer
When does TCA occur (respiration) During aerobic respiration
What is the main regulatory enzyme of TCA cycle Isocitrate Dehydrogenase
Where does TCA occur Mitochondria
What are the starting materials of TCA cycle? Acetyl CoA, NAD+, FAD, GDP, and Pi
What are the products of TCA cycle? CO2, NADH, FADH2, GTP
What is the recycled 4 carbon compound of TCA cycle? Oxaloacaetate
Which dehydrogenase reduces FAD to FADH2 in TCA cycle? Succinate dehydrogenase
Which dehydrogneases reduce NAD+ to NADH in the TCA cycle? isocitrate dehydrogenase,aplha-ketoglutarate dehydrogenase, and malate dehydrgonenase
Why is TCA cycle completely aerobatic even though it does not use oxygen in cycle? The TCA cycle is aerobatic because it produces NADH which is oxidized in the OX-PHOS. OX-PHOS requires O2 and therefore if not O2 is avialible then OX-Phos doesnt occure. This results in a build up in NADH which inhibits TCA cycle and PDH.
What enzyme produces oxaloacetate from pyruvate? pyruvate carboxylase
How is Isocitrate dehydrogenase activated? ADP and CA2+ and isocitrate
If a patient is deficient in panthothenic acid, which cofactor of TCA will this affect? Co-enzyme A (CoA-SH)
If a patient is deficient in Niacin, which cofactor of TCA will this affect NAD+/NADH
If a patient is deficient in riboflavin, which cofactor of TCA will this affect? FAD/FADH2
If a patient is deficient in Thiamine pyrophospate (TPP), which cofactor of TCA will this affect? Thiamine
If a patient is deficient in Lipoic acid, which cofactor of TCA will this affect? lipomide
Pyruvate can be transaminated into which amino acid? alanine
Oxalacetate can be transaminated into which amino acid? aspartate
alpha-ketoglutarate can be transaminated into which amino acid? glutamate
What cofactors are required for alpha-ketoglutarate dehydrogenase? NAD+, thiamine pyrophosphate (PPT), and lipoic acid
What can oxaloacetate be converted to in order to cross the mitochondrial membrane? Malate or aspartate
What does the TCA cycle produce with amino acid carbons in the fed and fasted states? Fed states- CO2 and Fatty acids for triglycerides through citrate. Fasted state- carbon source for gluconeogensis as oxaloacetate.
How is TCA cycle connected to heme synthesis? Succinyl CoA leaves for heme snythesis in liver
How is TCA cycle connected to neurotransmitter synthesis? alpha-ketoglutarate leaves for glutamate and GABA snythesis
What is the rate limiting enzyme in the TCA cycle? isocitrate dehydrogenase
Created by: 721091545