Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
HDN
Intro, Disease Process, Classification & Pathogenesis
| Question | Answer |
|---|---|
| Hemolytic disease of the newborn is? | destruction of RBCs of the fetus & neonate by AB produced by the mother |
| Th mother is stimulated to produce ABs by? | curent or previous pregnancies or by transfusion |
| HDN is most commonly caused by | anti-D and other Rh blood group ABs |
| During pregnancy there is fetomaternal hemorrhage | which are RBCs from fetus enter the mothers circulation, 0.1ml |
| Mother forms antibodies against | paternal antigens |
| IgG antibodies cross placenta | and bind to fetal RBCs |
| D hemolytic disease | caused by anti-D alone or in combo with anit-C or anti-E |
| Other hemolytic disease | caused by other Rh ABs or blood group ABS, anti-K, anti-c |
| ABO hemolytic disease | usually caused by anti-A,B in O women |
| FHM occurs in # of pregnancy | 75%, usually immediately after delivery |
| Other causes of FHM | amniocentesis, abortion, chorionic villus sampling, cordocentesis,etopic preg, blunt trauma to abdomen |
| Since advent of Rh immune globulin | < 1% of D neg mothers exhibit immunization |
| Incidence of 'D' HDN = | 18% in untreated D neg mothers of D pos infants |
| Prevalance of non-anti-D HDN = | <0.3% |
| Transfusion of D pos red cell products | to women of child bearing age should be avoided |
| IF D pos transfusion necessary | then Rh IG prophylacic treatment |
| Hemolysis & Erythropoiesis | Maternal IgG AB attaches on fetal RBCs; AB/AG complex removed by macrophages in spleen; fetal bone marrow & hempietic tissue in liver & spleen increase RBC production |
| Anemia | moderate to severe depending on #RBCs destroyed; severe anemia may lead to hydrops fetalis from enlarged liver and spleen; |
| Anemia cont | RBC destruction continues after birth as long as maternal AB in system |
| Hydrops fetalis | severe edema, effusions, ascites |
| Bilirubnemia | RBC lysis casuse release of HgB which is metabolized into indirect bikirubin; then may be transported across placenta & conjugated in maternal liver to direct bilirubin & then excreted |
| Bilirubnemia cont | total bili elevated in fetal serum & amniotic fluid, but not harmful; after birth, accumulation of indirect bili to toxic levels & can cause brain damage |
Created by:
dodge1500
Popular Laboratory Science sets