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Ch. 5 review
Physiology 2420
| Question | Answer |
|---|---|
| Proteins on a target cell that recognize and bind a chemical messenger; in sensory systems, detectors of stimuli | receptors |
| the process by which the binding of chemical messenger to receptors brings about a response in a target cell | signal transduction |
| type of chemical messenger for which the secretory cell and target cell are the same | autocrine |
| type of chemical messenger that communicates with neighboring cells by simple diffusion | paracrine |
| chemical messenger released from the axon terminal of a neuron | neurotransmitter |
| chemical messengers released from endocrine cells or glands into the interstitial fluid, where they then diffuse into the blood and travel to target cells | hormones |
| proteins that stimulate the growth and proliferation of a particular type of tissue | growth factors |
| plasma proteins that form blood clots when activated | clotting/coagulating factors |
| peptides or proteins that are usually secreted by immune cells in response to a stimulus | cytokines |
| at a synapse, a neuron that transmits signals to a second neuron or an effector cell | presynaptic neuron |
| cell that receives communication from a neurotransmitter released at a synapse | postsynaptic cell |
| special class of hormones released by neurosecretory cells | neurohormones |
| Name the 4 functional classifications of chemical messengers: | 1. Paracrine 2. Autocrine 3. Neurotransmitter 4. Hormone |
| molecules are lipid-soluble and therefore readily cross the plasma membrane, but they do not dissolve in water | lipophilic (hydrophobic) |
| molecules are water soluble and therefore do not cross the plasma membrane | lipophobic (hydrophilic) |
| What are the 5 major chemical classes of messengers? | 1. Amino acids 2. Amines 3. Peptides/proteins 4. Steroids 5. Eicosanoids |
| Amino acids are lipophobic/lipophilic? | lipophobic |
| Amine acids are lipophobic/lipophilic? | lipohobic |
| Peptide/Proteins are lipophobic/lipophilic? | lipophobic |
| Steroids are lipophobic/lipophilic? | lipophilic |
| Eicosanoids are lipophobic/lipophilic? | lipophilic |
| amine compounds that contain a catechol group are are derived from the amino acid tyrosine | catecholamines |
| Name 3 catecholamines: | 1. dopamine 2. norepinephrine 3. epinephrine |
| Steroids are a class of compounds derived from ___________. | cholesterol |
| ___________ is the precursor for norepinphrine. | dopamine |
| time it takes for half the amount of a molecule to be degraded | half-life |
| The strength of the binding between a messenger and its receptor is termed __________. | affinity |
| Ligands that bind to receptors and produce a biological response are called __________. | agonist |
| __________ are ligands that binds to receptors but do not produce a response. | antaqonist |
| What are the three categories that membrane-bound receptors fall into? | 1. channel-linked receptors 2. enzyme-linked receptors 3. G protein-linked receptors |
| Ion channels that open or close in response to the binding of a chemical to a receptor or to the channel are called _________ channels. | ligand-gated |
| protein that functions as both an ion channel and a receptor; binding of a messenger to the receptor portion of the protein opens the channel | channel-linked receptor |
| an intracellular messenger molecule that is produced in response to the binding of an extracellular messenger (the first messenger) to a receptor | second messenger |
| cytosolic calcium-binding protein; modulates the activity of intracellular proteins. | calmodulin |
| plasma membrane proteins that function as both a receptor and an enzyme | enzyme-linked receptors |
| plasma membrane receptor that is coupled to a G protein | G-protein linked receptor |
| membrane proteins with the ability to bind guanosine nucleotides; function in coupling an extracellular messenger to a response inside the target cell | G protein |
| What is the most common second messenger? | cAMP |
| a series of sequential steps that progressively increase in magnitude | cascade |
| What are the two organ systems that are specialized for long-distance communication? | the nervous system and the endocrine system |
| What are the three types of cell surface receptors? | 1. channel-linked receptors 2. enzyme-linked receptors 3. G Protein-linked receptors |