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Chapter 14

Therapeutic Drug Monitoring and Toxicology

TDM came about in order to help improve the outcome of certain types of drug therapy. Some medications have toxic effects at blood levels only slightly higher than the therapeutic level.
Toxicity may cause damage to organs such as the liver and kidneys. (Hepatotoxicity, Nephrotoxicity)
Dosage and timing of dosage as well as route of administration, and half life all play a part in hitting the correct therapeutic level of drug for the patient.
The half life of a drug is the time it takes for the concentration of drug to decrease by half.
If the dose is delivered at every half life the drug should reach a steady state after 4 to 5 half lives.
The half life can be effected by each individuals genetic make up and must be determined from pharmacokinetic calculations.
Some drugs are measured by the effect on the patient I.E. PT/INR and coumadin, or Furosemide on blood pressure.
Created by: Mgoodall