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APHY 201 Exam 3a1
Ch. 13 Table - Plasma Clotting Factors and Pathways
| Number | Name | Function | Pathway |
|---|---|---|---|
| I | Fibrinogen | Converted to fibrin | Common |
| II | Prothrombin | Converted to thrombin (enzyme) | Common |
| III | Tissue thromboplastin | Cofactor | Extrinsic |
| VIII | Antihemophilic factor | Cofactor | Intrinsic |
| IX | Plasma thromboplastin component; Christmas factor | Enzyme | Intrinsic |
| X | Stuart-Prower factor | Enzyme | Common |
| XII | Hageman factor | Enzyme | Intrinsic |
| what is thrombin? | thrombin (factor IIa) is a crucial serine protease enzyme in the blood coagulation cascade; triggers hemostasis by converting soluble fibrinogen into insoluble fibrin, which forms the meshwork of a blood clot | ||
| detail the extrinsic pathway of fibrin formation | 1. external trauma 2. damaged cells release FIII 3. FIII binds with FVII(a) to form VII complex incl. Ca2+ and phospholipids 4. complex converts FX to FXa | ||
| detail the intrinsic pathway of fibrin formation | 1. internal vessel damage 2. FXIIa activated by activators (collagen etc) 3. FXIIa activates FXI 4. FXIa in Ca2+ presence activates FIXa 5. FIXa binds with FVIIIa, Ca²⁺, and platelets to form VIII complex, which activates Factor Xa | ||
| detail the common pathway of fibrin formation | 1. prothrombinase formation: FXa binds with FVa, Ca²⁺, and platelets | 2. FV complex (prothrombinase WITH CALCIUM & PHOSPHOLIPIDS) converts prothrombin (FII) to thrombin (FIIa) | 3. thrombin cleaves fibrinogen (FI) into soluble fibrin monomers 4. FXIIIa cross-links fibrin monomers into an insoluble mesh clot. |
| what is factor I's name, function, and pathway? | fibrinogen, converted to fibrin, common | ||
| what is factor II's name, function, and pathway? | prothrombin, converted to thrombin (enzyme), common pathway | ||
| what is factor III's name, function, and pathway? | tissue thromboplastin, cofactor function, extrinsic pathway | ||
| what is factor VIII's name, function, and pathway? | antihemophilic factor, cofactor, intrinsic | ||
| what is factor IX's name, function, and pathway? | Christmas factor, enzyme, intrinsic | ||
| what is factor X's name, function, and pathway? | Stuart-Prower factor, enzyme, common pathway | ||
| what is factor XII's name, function, and pathway? | Hageman factor, enzyme, intrinsic pathway | ||
| what produces prothrombin activator? | factor X | ||
| what converts prothrombin to thrombin? | prothrombin activator (FV complex with calcium and phospholipids) | ||
| thrombin speeds up the formation of prothrombin activator. this is associated with what kind of feedback? | positive feedback |
Created by:
elianayu
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