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CV 3-4

BDK

Pharmacologic CategoryGeneric NameBrand NameCommon IndicationsEssential Knowledge
Omega-3 fatty acids icosapent ethyl (PO) Vascepa Hypertriglyceridemia Key Side Effects: eructation, arthralgia Other Notes: can prolong bleeding time when used with other medication that can increase bleeding risk, use caution with fish/shellfish allergy
Omega-3 fatty acids omega-3 ethyl esters (PO) Lovaza Hypertriglyceridemia Key Side Effects: dyspepsia, eructation, fishy aftertaste Other Notes: can prolong bleeding time when used with other medication that can increase bleeding risk, use caution with fish/shellfish allergy
HMG-CoA reductase inhibitorS atorvastatin (PO) lovastatin (PO) pravastatin (PO) rosuvastatin (PO) simvastatin (PO) Liptor Altoprev Pravachol Crestor Zocor Dyslipidemia, CAD, stroke Key Side Effects: myopathy/rhabdomyolysis Other Notes: avoid excessive grapefruit juice intake, avoid in pregnancy and breastfeeding
Fibric acid derivative gemfibrozil (PO) Lopid Hypertriglyceridemia Key Side Effects: dyspepsia, myopathy/rhabdomyolysis, elevated hepatic transaminases
Fibric acid derivative fenofibrate (PO) Tricor, Trilipix Hypertriglyceridemia Key Side Effects: dyspepsia, myopathy/rhabdomyolysis, elevated hepatic transaminases
Cholesterol absorption inhibitor ezetimibe (PO) Zetia Dyslipidemia Key Side Effects: myalgias, diarrhea
Antiarrhythmic amiodarone (PO, IV) Pacerone, Nexterone Af (rhythm control), ventricular fibrillation, ventricular tachycardia hypothyroidism, hyperthyroidism, pulmonary toxicity, hepatotoxicity, epithelial keratopathy, photosensitivity BW: intended only for life-threatening arrhythmias; pulmonary toxicity, hepatotoxicity; proarrhythmic Other Notes: many drug interactions
Fibrinolytic alteplase (intracatheter, IV) Intracatheter: Cathflo Activase, IV: Activase Intracatheter: catheter clearance IV: STEMI, acute ischemic stroke, PE Key Side Effects: bleeding Other Notes: CI in patients with severe uncontrolled HTN
Vasodilator nitroglycerin (SL) Nitrostat ACS, stable angina Key Side Effects: headache, flushing, syncope, dizziness Other Notes: do not use with PDE-5 Inhibitors; tachyphylaxis (tolerance/ ↓ effectiveness); can aggravate angina causes by hypertrophic cardiomyopathy
Antiplatelet agent aspirin (PO) Bayer, Bufferin, Ecotrin ACS, stable angina, pain, stroke Key Side Effects: dyspepsia, heartburn, bleeding Other Notes: CI in NSAID or salicylate allergy, children and teenagers with viral infection (due to Reye’s syndrome), can cause tinnitus in salicylate overdose
Antiplatelet agent ticagrelor (PO) Brilinta ACS Key Side Effects: bleeding, dyspnea US Boxed Warnings: significant, sometimes fatal bleeding; do not exceed aspirin >100 mg daily due to reduced ticagrelor effectiveness
Antiplatelet agent clopidogrel (PO) Plavix CAD, stroke Key Side Effects: bleeding US Boxed Warnings: diminished effectiveness in poor metabolizers
Anticoagulant heparin (IV, SQ) - ACS, VTE Key Side Effects: bleeding, hyperkalemia (chronic use), HIT
Anticoagulant, low molecular weight heparin enoxaparin (SQ) Lovenox ACS, VTE Key Side Effects: bleeding, HIT US Boxed Warnings: increased risk of epidural or spinal hematoma in patients undergoing spinal puncture Other Notes: do not expel air bubble from syringe prior to injection
Anticoagulant, vitamin K antagonist warfarin (PO) Coumadin, Jantoven AF (stroke prevention), VTE bleeding, skin necrosis BW:bleeding risk Other Notes: narrow therapeutic index drug (monitor INR) Other Notes: dose dependent tablet colors; consistent vitamin K intake recommended; many drug interactions
Anticoagulant, factor Xa inhibitor rivaroxaban (PO) Xarelto AF (stroke prevention), VTE, PAD Key Side Effects: bleeding US Boxed Warnings: premature discontinuation increases risk of thrombotic events; increased risk of epidural or spinal hematoma in patient undergoing spinal puncture
Anticoagulant, factor Xa inhibitor apixaban (PO) Eliquis AF (stroke prevention), VTE Key Side Effects: bleeding US Boxed Warnings: premature discontinuation increases risk of thrombotic events; increased risk of epidural or spinal hematoma in patient undergoing spinal puncture
Anticoagulant, direct thrombin inhibitor dabigatran (PO) Pradaxa AF (stroke prevention), VTE bleeding, dyspepsia BW: premature d/c increases risk of thrombotic events; increased risk of epidural or spinal hematoma in patients undergoing spinal puncture swallow whole; dispense and store in original packaging; discard 4 months after opening
Created by: beezy41
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