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Endocrine 2-3
BDK
| Pharmacologic Category | Generic Name | Brand Name | Classification | Common Indications | Essential Knowledge |
|---|---|---|---|---|---|
| CNS stimulant, anorexiant | phentermine (PO) | Adipex-P | CS-IV | Obesity | tachycardia, hypertension, nausea, dizziness, xerostomia, agitation Other Notes: only approved for short-term use; CI in those with a history of cardiovascular disease or drug abuse, pregnancy, hyperthyroidism, or within 14 days of MAOI therapy |
| Thyroid product | thyroid, desiccated (PO) | Armour Thyroid | Hypothyroidism | Key Side Effects: weight loss, palpitations, diarrhea, insomnia, heat intolerance US Boxed Warnings: not intended for use for weight loss narrow therapeutic index, not all generics are equivalent | |
| Thyroid product | levothyroxine (PO, IV) | Synthroid, Levoxyl, Unithroid | Hypothyroidism | Key Side Effects: weight loss, palpitations, diarrhea, insomnia, heat intolerance US Boxed Warnings: not intended for use for weight loss narrow therapeutic index, not all generics are equivalent | |
| Phosphodiesterase-5 enzyme (PDE5) inhibitor | tadalafil (PO) | Cialis, Adcirca | ED, BPH, PAH | Key Side Effects: priapism, headache, flushing, visual disturbance, dyspepsia, back pain (mostly with tadalafil), hearing or vision loss (rare) Other Notes: CI with concomitant use of nitrates (may cause severe hypotension) | |
| Phosphodiesterase-5 enzyme (PDE5) inhibitor | sildenafil (PO) | Viagra, Revatio | ED, PAH | Key Side Effects: priapism, headache, flushing, visual disturbance, dyspepsia, back pain (mostly with tadalafil), hearing or vision loss (rare) Other Notes: CI with concomitant use of nitrates (may cause severe hypotension) | |
| Vitamin D analog | cholecalciferol (vitamin D3) (PO) | - | OTC | dietary supplement, osteoporosis prevention | Key Side Effect: vitamin D toxicity (nausea, vomiting, loss of appetite, constipation, confusion, weakness) Other Note: CI with hypercalcemia |
| Bisphosphonate | alendronate (PO) | Fosamax | Osteoporosis | dyspepsia, gastroesophageal reflux disease, hypocalcemia, atypical fractures, osteonecrosis of the jaw CI in patients with hypocalcemia or abnormalities of the esophagus; administer ≥30 minutes before food/drink; remain upright for 30 minutes | |
| Androgen | testosterone gel (topical) | AndroGel, Fortesta, Vogelxo | CS-III | Male hypogonadism | contact dermatitis, acne, increased prostate specific antigen (PSA), emotional lability, hypertension BW: secondary exposure may result in virilization CI in males with breast or prostate cancer and pregnant women; apply in the morning |
| Progestin | medroxyprogesterone (PO) | Provera | Abnormal uterine bleeding, secondary amenorrhea | acne, abnormal menstrual bleeding, headache, amenorrhea, weight gain BW: increased risk of breast cancer; should not be used for dementia or CV prevention CI in VTE disorders, CVD, HR+ tumors, abnormal genital bleeding, hepatic impairment | |
| Estrogen derivative | estradiol (transdermal, PO) | Transdermal: Climera, Vivelle Dot PO: Estrace | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | CI in VTE disorders, CVD, HR+ tumors, abnormal genital bleeding, hepatic impairment BW: increased risk of breast cancer; should not be used for dementia or CV prevention, do not use estrogen alone in patient with a uterus | |
| Estrogen derivative | estrogens, conjugated (equine) (PO, topical) | Premarin | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | CI in VTE disorders, CVD, HR+ tumors, abnormal genital bleeding, hepatic impairment BW: increased risk of breast cancer; should not be used for dementia or CV prevention, do not use estrogen alone in patient with a uterus | |
| Contraceptive | norgestrel and ethinyl estradiol (PO) | Crysell-28, Low-Ogestrel | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD | |
| Contraceptive | norgestimate and ethinyl estradiol (PO | Sprintec, tri-sprintec | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD | |
| Contraceptive | norethindrone, ethinyl estradiol, and ferrous fumarate (PO) | Lo Loestrin Fe, Microgestin Fe | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD | |
| Contraceptive | norethindrone and ethinyl estradiol (PO) | Junel, loestrin, microgestin | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD | |
| Contraceptive | levonorgestrel and ethinyl estradiol (PO) | Lutera, Levora, Seasonique | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD | |
| Contraceptive | drospirenone and ethinyl estradiol (PO) | Yasmin 28, Yaz | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD |