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Endocrine 2-3

BDK

Pharmacologic CategoryGeneric NameBrand NameClassificationCommon IndicationsEssential Knowledge
CNS stimulant, anorexiant phentermine (PO) Adipex-P CS-IV Obesity tachycardia, hypertension, nausea, dizziness, xerostomia, agitation Other Notes: only approved for short-term use; CI in those with a history of cardiovascular disease or drug abuse, pregnancy, hyperthyroidism, or within 14 days of MAOI therapy
Thyroid product thyroid, desiccated (PO) Armour Thyroid Hypothyroidism Key Side Effects: weight loss, palpitations, diarrhea, insomnia, heat intolerance US Boxed Warnings: not intended for use for weight loss narrow therapeutic index, not all generics are equivalent
Thyroid product levothyroxine (PO, IV) Synthroid, Levoxyl, Unithroid Hypothyroidism Key Side Effects: weight loss, palpitations, diarrhea, insomnia, heat intolerance US Boxed Warnings: not intended for use for weight loss narrow therapeutic index, not all generics are equivalent
Phosphodiesterase-5 enzyme (PDE5) inhibitor tadalafil (PO) Cialis, Adcirca ED, BPH, PAH Key Side Effects: priapism, headache, flushing, visual disturbance, dyspepsia, back pain (mostly with tadalafil), hearing or vision loss (rare) Other Notes: CI with concomitant use of nitrates (may cause severe hypotension)
Phosphodiesterase-5 enzyme (PDE5) inhibitor sildenafil (PO) Viagra, Revatio ED, PAH Key Side Effects: priapism, headache, flushing, visual disturbance, dyspepsia, back pain (mostly with tadalafil), hearing or vision loss (rare) Other Notes: CI with concomitant use of nitrates (may cause severe hypotension)
Vitamin D analog cholecalciferol (vitamin D3) (PO) - OTC dietary supplement, osteoporosis prevention Key Side Effect: vitamin D toxicity (nausea, vomiting, loss of appetite, constipation, confusion, weakness) Other Note: CI with hypercalcemia
Bisphosphonate alendronate (PO) Fosamax Osteoporosis dyspepsia, gastroesophageal reflux disease, hypocalcemia, atypical fractures, osteonecrosis of the jaw CI in patients with hypocalcemia or abnormalities of the esophagus; administer ≥30 minutes before food/drink; remain upright for 30 minutes
Androgen testosterone gel (topical) AndroGel, Fortesta, Vogelxo CS-III Male hypogonadism contact dermatitis, acne, increased prostate specific antigen (PSA), emotional lability, hypertension BW: secondary exposure may result in virilization CI in males with breast or prostate cancer and pregnant women; apply in the morning
Progestin medroxyprogesterone (PO) Provera Abnormal uterine bleeding, secondary amenorrhea acne, abnormal menstrual bleeding, headache, amenorrhea, weight gain BW: increased risk of breast cancer; should not be used for dementia or CV prevention CI in VTE disorders, CVD, HR+ tumors, abnormal genital bleeding, hepatic impairment
Estrogen derivative estradiol (transdermal, PO) Transdermal: Climera, Vivelle Dot PO: Estrace Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause CI in VTE disorders, CVD, HR+ tumors, abnormal genital bleeding, hepatic impairment BW: increased risk of breast cancer; should not be used for dementia or CV prevention, do not use estrogen alone in patient with a uterus
Estrogen derivative estrogens, conjugated (equine) (PO, topical) Premarin Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause CI in VTE disorders, CVD, HR+ tumors, abnormal genital bleeding, hepatic impairment BW: increased risk of breast cancer; should not be used for dementia or CV prevention, do not use estrogen alone in patient with a uterus
Contraceptive norgestrel and ethinyl estradiol (PO) Crysell-28, Low-Ogestrel Contraception, acne nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD
Contraceptive norgestimate and ethinyl estradiol (PO Sprintec, tri-sprintec Contraception, acne nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD
Contraceptive norethindrone, ethinyl estradiol, and ferrous fumarate (PO) Lo Loestrin Fe, Microgestin Fe Contraception, acne nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD
Contraceptive norethindrone and ethinyl estradiol (PO) Junel, loestrin, microgestin Contraception, acne nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD
Contraceptive levonorgestrel and ethinyl estradiol (PO) Lutera, Levora, Seasonique Contraception, acne nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD
Contraceptive drospirenone and ethinyl estradiol (PO) Yasmin 28, Yaz Contraception, acne nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain BW: CV events in women >35 years old who smoke CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and CVD
Created by: beezy41
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