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CNS 2-3

BDK

Pharmacologic CategoryGeneric NameBrand NameCommon IndicationsEssential Knowledge
Second- generation antipsychotic risperidone (PO, IM) PO: Risperdal IM: Risperdal Consta Schizophrenia Key Side Effects: sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia, US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Second- generation antipsychotic olanzapine (PO, IM) Zyprexa Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants Key Side Effects: sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia, US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Second- generation antipsychotic lurasidone (PO) Latuda Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants sedation, EPS, constipation, orthostatic hypotension, weight gain BW: antidepressants increase the risk of suicidal thinking, elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death CI with strong 3A4
Second- generation antipsychotic quetiapine (PO) Seroquel, Seroquel XR Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants sedation, EPS, constipation, orthostatic hypotension, weight gain, BW: antidepressants increase the risk of suicidal thinking in the youth; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Second- generation antipsychotic aripiprazole (PO, IM) PO/IM: Abilify; IM: Aristada Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants akathisia, restlessness, sedation, EPS, constipation, orthostatic hypotension, weight gain BW: increase the risk of suicidal thinking and behavior in youth; elderly patients with dementia-related psycho treated with antipsychotic drugs at increased risk
Second- generation antipsychotic clozapine (PO) Clozaril Treatment- resistant schizophrenia sedation, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain BW: may cause severe neutropenia; may cause orthostatic hypotension, bradycardia, and syncope; seizures; fatal myocarditis and cardiomyopathy; elderly patients
First-generation antipsychotic haloperidol (PO, IV, IM) Haldol Schizophrenia Key Side Effects: sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation, US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Antimigraine rizatriptan (PO) Maxalt Migraine Key Side Effects: fatigue, somnolence, dizziness, chest tightness, paresthesias Other Notes: CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
Antimigraine sumatriptan (PO, intranasal, SQ) Imitrex Migraine Key Side Effects: fatigue, somnolence, dizziness, chest tightness, paresthesias Other Notes: CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
Antimanic agent lithium (PO) Lithobid Bipolar disorder tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia, GI upset BW: ability to promptly monitor levels is necessary Other Notes: narrow therapeutic index drug; avoid in pregnancy
Cholinesterase inhibitor donepezil (PO, transdermal) PO: Aricept, Transdermal: Adlarity Dementia Key Side Effects:L nausea, vomiting, diarrhea
N-methyl D- aspartate (NMDA) antagonist memantine (PO) Namenda Dementia Key Side Effects: constipation, confusion, dizziness, headache
Decarboxylase inhibitor (carbidopa), dopamine precursor (levodopa) carbidopa and levodopa (PO) Sinemet, Sinemet CR Parkinson's disease Key Side Effects: nausea, orthostatic hypotension, dyskinesias Other Notes: CI within 14 days of MAOI, CI in narrow-angle glaucoma; do not abruptly discontinue
Dopamine agonist ropinirole (PO) Requip Parkinson's disease, RLS Key Side Effects: nausea, hallucinations, dizziness, drowsiness, compulsive behaviors, orthostasis
Dopamine agonist pramipexole (PO) Mirapex Parkinson's disease, RLS Key Side Effects: nausea, hallucinations, dizziness, drowsiness, compulsive behaviors, orthostasis
Selective alpha2a agonis guanfacine (PO) Intuniv ADHD, HTN Key Side Effects: bradycardia, hypotension, sedation, skin rash, xerostomia, constipation Other Notes: do not abruptly discontinue
CNS stimulant (C-II) methylphenidate (PO, transdermal) PO: Concerta, Ritalin Patch: Daytrana ADHD, narcolepsy Key Side Effects: insomnia, headache, anxiety, weight loss, decreased appetite, hypertension US Boxed Warnings: high potential for abuse, Other Notes: CI within 14 days of MAOI
CNS stimulant (C-II) lisdexamfetamine (PO Vyvanse ADHD Key Side Effects: insomnia, headache, anxiety, weight loss, decreased appetite, hypertension US Boxed Warnings: high potential for abuse, Other Notes: CI within 14 days of MAOI
CNS stimulant (C-II) dextroamphetamine and amphetamine (PO) Adderall, Adderall XR ADHD, narcolepsy Key Side Effects: insomnia, headache, anxiety, weight loss, decreased appetite, hypertension US Boxed Warnings: high potential for abuse, Other Notes: CI within 14 days of MAOI
CNS stimulant (C-II) dexmethylphenidate (PO Focalin, Focalin XR ADHA Key Side Effects: insomnia, headache, anxiety, weight loss, decreased appetite, hypertension US Boxed Warnings: high potential for abuse, Other Notes: CI within 14 days of MAOI
Created by: beezy41
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