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PHO 1-2

BDK

Pharmacologic CategoryGeneric NameBrand NameClassificationCommon IndicationsEssential Knowledge
Water-soluble vitamin Folic acid - OTC Folic acid deficiency (manifests as macrocytic anemia), prevention of neural tube defects in pregnancy Key Side Effects: no major side effects
Water-soluble vitamin cyanocobalamin (b12) - PO/SL: OTC Vitamin B12 deficiency (manifests as macrocytic anemia) Key Side Effects: no major side effects
Iron supplement ferrous sulfate (PO) FeroSul, SlowFe OTC Iron deficiency anemia Key Side Effects: nausea, stomach upset, constipation (dose-related), dark and tarry stools US Boxed Warning: accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old
Partial opioid agonist and opioid antagonist buprenorphine and naloxone (SL) Suboxone CS-III Opioid use disorder opioid withdrawal syndrome in opioid-dependent populations, constipation, headache, diaphoresis, potentially life-threatening respiratory depression (when combined with other CNS and respiratory depressants)
Opioid antagonist naloxone (IV, IM, SQ, intranasal) Narcan Nasal Spray, Zimhi Nasal Spray OTC Opioid overdose Key Side Effects: opioid withdrawal syndrome in opioid-dependent populations, pain
Opioid and nonopioid analgesic combination codeine and acetaminophen (PO) Tylenol with Codeine #3, Tylenol with Codeine #4 CS-III Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression BW: opioid effects, use with 3A4 drugs, death after tonsillectomy or adenoidectomy in ultra metabolizers of codeine, hepatotoxicity
Opioid and nonopioid analgesic combination oxycodone and acetaminophen (PO) Percocet, Endocet CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression, BW: opioid effects, 3A4 inhibitors, hepatotoxicity
Opioid and nonopioid analgesic combination hydrocodone and acetaminophen (PO) Lortab, Vicodin, Norco CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression, BW: opioid effects, 3A4 inhibitors, hepatotoxicity
Central & analgesic; partial opioid agonist tramodol Ultram, Ultram ER CS-IV Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression BW: opioid effects, use with 3A4 drugs, death after tonsillectomy or adenoidectomy in ultra metabolizers of tram lowers seizure threshold
Analgesic (non- opioid), antipyretic acetaminophen (PO, PR, IV) PO/PR: Tylenol, IV: Ofirmev PO, PR: OTC Pain, fever Key Side Effects: nausea, vomiting, increased hepatic transaminases US Boxed Warnings: total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity
Opioid analgesic methadone (PO, IV) Dolophine CS-II Opioid use disorder, severe chronic pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, , QTc prolongation BW: opioid effects and QTc prolongation, torsades de pointes, major CYPs
Opioid analgesic oxycodone (PO) OxyContin, Roxicodone CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus BW: opioid effects (addiction, resp, depression, use with benzo or alc, death) + major CYPs
Opioid analgesic morphine (immediate release) (PO, IV, IM, PR) IV: Duramorph, Infumorph CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus BW: opioid effects (addiction, resp, depression, use with benzo or alc, death)
Opioid analgesic morphine (extended release) (PO) MS Contin, Kadian CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus BW: w/ alc leads to fatal OD + opioid effects (addiction, resp, depression, use with benzo or alc, death)
Opioid analgesic hydromorphone (PO, IV) Dilaudid CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus BW: med errors, only use in opioid tolerant + opioid effects (addiction, resp, depression, use with benzo or alc, death)
Opioid analgesic fentanyl (transdermal, IV) Transdermal: Duragesic, IV: Sublimaze CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus BW: OD between dosage forms, 3A4 + opioid effects (addiction, resp, depression, use with benzo or alc, death)
Created by: beezy41
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