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PHO 3
BDK
| Pharm Class | Generic | Brand | Common Indications | Essential Knowledge |
|---|---|---|---|---|
| Antimetabolite (folic acid antagonist) | methotrexate (PO, IV, IT) | Trexall | Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors | increased LFTs, BOXED WARNING: toxic reactions, fetal death, bone marrow supp, aplastic anemia, toxicity with NSAIDs (GI and CV), hepatotoxicity, lung disease, interstitial pneumonitis, use folic acid supplementation |
| Antineoplastic agent, platinum- based compound | cisplatin (IV, IT, IP) | Kemoplat | Advanced bladder, ovarian, and testicular cancer; various cancers | Key Side Effects: bone marrow suppression, nausea, vomiting, nephrotoxicity, neurotoxicity, ototoxicity US Boxed Warnings: may cause severe myelosuppression, nausea and vomiting, renal toxicity, and dose-related neuropathy |
| Antineoplastic agent, anthracycline | doxorubicin (IV) | Adriamycin | Adjuvant therapy for breast cancer, various cancers | cardiomyopathy, alopecia, nausea, vomiting, bone marrow suppression BW: may cause cardiomyopathy, myelosuppression, secondary malignancies; extravasation can result in severe local tissue injury and necrosis, red discoloration of liquids |
| Antineoplastic agent, monoclonal antibody | pembrolizumab (IV) | Keytruda | Various cancers | Key Side Effects: peripheral edema, pruritus, skin rash, endocrine and metabolic abnormalities, constipation, diarrhea, nausea, vomiting, hematuria, anemia, increased liver enzymes, fatigue, musculoskeletal pain, increased serum creatinine, dyspnea |
| Aromatase inhibitor | anastrozole (PO) | Arimidex | HR + breast cancer | Key Side Effects: fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis Other Notes: cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy) |
| Selective estrogen receptor modulator (SERM) | tamoxifen (PO) | Soltamox | HR + breast cancer | hot flashes/night sweats, vaginal bleeding/discharge, decrease bone density BW: increased risk for uterine or endometrial cancer and DVT/VTE contraception should be used in premenopausal females due to teratogenicity of the drug; do not use with warfarin |