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Carbs part 2

Carbohydrates part 2

Genetic Defects in Metabolism 1. Glycogen Storage Disease 2. Galactosemia -syndrome in infants where they fail to thrive
Methods of Measurement 1. Reducing Methods-glucose is a reducing sugar and will reduct agents to form and end product 2. Enzymatic-measurement of hydrogen peroxide can be measured by slide reaction
Trinder Reaction Coupled reaction Dye colored is proportional to glucose
Hexokinase uses G6P to convert NADP to NADPH is proportional to amount of glucose
What is most used Glucose oxidase or Glucose Hexokinase? Glucose oxidase
Fasting Glucose Normal range- 70-99 mg/dL Impaired range- 100-125 mg/dL Diabetes- 126 mg/dL or higher
Self Monitoring Glucose Type 1- 3-4 times a day Type 2- 1-2 times a day
2 Hour Post Prandial Test 75g glucose solution is given 2 hours later glucose level is drawn if >200mg/dL additional testing is preformed
Glycemic Control Doctors can check how patients have been dieting for at least 3 months
Ketone Methods 1.Colormetric (Gerhardts and Sodium niroprusside 2.Enzymatic (Beta-hydroxybutryrate dehydrogenase)
Microalbumin elevated glucose causes diabetic renal nephropathy early signs are proteins in urine normal 20-300mg/day
Diagnosis of Abnormalities 1. Islet Autoantibody Testing 2. Insulin Testing
C-Peptide Proinsulin- secreted by b-cells precursor to insulin
C-Peptide Corrects insulin structure High insulin=High C-Pep
Endogenous C-Peptide Inside Body High Insulin High C-Peptide
Exogenous C-Peptide Injected in the body High Insulin C-Peptide doesn't increase C-Peptide not contained in Exogenous insulin
Created by: nccrevier