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Immune Complex III

Immunology and Serology

QuestionAnswer
How is the formation of immune complexes protective? The formation of immune complexes is protective because complexes facilitate clearance of antigens and invading microorganisms by phagocytic system
What happens in immune complex reactions? Ag/Ab complexes form in fluid phase of tissues or blood and assume unique biologic functions such as interactions with complement or cellular receptors
What are some examples of immune complex (Type III) reactions? Arthus reactionSerum sicknessSome autoimmune disease such as glomerulonephritis in SLE
What happens when Ab reacts with soluble Ag in circulation? The formation of complexes that may disseminate and lodge in any tissue with large filtration area and cause lesion of immune complex disease.
What happens when there is a formation of complexes that may disseminate and lodge in any tissue with large filtration area and cause lesion of immune complex disease? experimental Arthus reaction, farmer’s lung disease
What happens when Ab reacts with structural Ags that form part of cell surface membranes or with fixed intercellular structures such as basement membranes? serum sickness = develops within 1 to 2 weeks after initial exposure or repeated exposure by injection of heterologous serum protein
Created by: Mgoodall