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WBC Maturation

Practice for WBC essay

Lives in bone marrow, finely reticular nucleus (folded, irregular, cleaved), scant cytoplasm Monoblast
Lives in BM ,large cell, nucleus somewhere between finely reticular and foamy, kidney bean shaped, cytoplasm is a little azurophilic (grainy/ground glass) Promonocyte
Lives in BM or peripheral blood. Large cell, nucleus is foamy, twisted, in segments (irregularly shaped), cytoplasm is grey, grainy/ground glass Mononcyte
The cell is kinda big, the nucleus is a little more dense than other blasts and round to oval, Cytoplasm is kind of grainy, Robin’s egg blue Lymphoblast
Little bigger than an RBC, nucleus is more dense, nearly no cytoplasm Prolymphocyte
About the same size as an RBC, nucleus stay fine but dense, cytoplasm stays small unless the cell is in a reactive state and may have 6 to 8 azurophilic granules Lymphocyte
Lives in the bone marrow, nucleus is finely reticular with nucleoli present, the cytoplasm is basophilic, no granules yet Myeloblast
Lives in the BM, Nucleoli begin to fade, the cytoplasm is basophilic and primary granules are forming, myeloperoxidase is forming in the granules Promyelocyte
Lives in the bone marrow, nucleus is round to oval and flat on one side, the nuclear material is starting to clump. We have the “Dawn of Neutrophilia” happening in the cytoplasm with the formation of secondary granules containing LAP and lysozyme. Myelocyte
Lives in the bone marrow, nucleus is indented, kidney bean shaped, nuclear condensation continues with chromatin/parachromatin starting to be seen, Tertiary granules are forming in the cytoplasm with geletinase lysozyme and acetyl tranferase Metamyelocyte
This is the first cell that normally will be seen in the peripheral blood and will be seen in BM as well, the sides of the nucleus will be parallel in a C or S shape and the indent will be half the nuclear width with chromatin/parachromaitin visible. Band
This cell lives in the peripheral blood and BM, It is a mature granulocyte, the nucleus will be segmented with filaments or the appearance filaments present, and chromatin/parachromatin present. The cytoplasm will have its full compliment of granules spec Seg
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