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IMC512 Renal

Flashcards 3: Salt and Water Reabsorption

QuestionAnswerAdditional Information
What does the clearance ratio (also known as the fraction excretion of sodium, FENa) report that GFR does not? Tubular function FENa is CNa/GFR (i.e. is nephron function corrected for the number of functioning nephrons)
The majority of salt and water reabsorption occurs in which nephron segment? Proximal Tubule
If a glucose appears in urine, which is greater: filtration rate of glucose or reabsorption rate of glucose? Filtration rate of glucose Because transporter mediated glucose reabsorption is saturable, it can be overwhelmed in diabetes mellitus when the rate of filtration from plasma exceeds the rate of reabsorption.
Thiazide diuretics block ____ in the distal tubule. NCC Mimicked by mutations in NCC known as Gitelman Syndrome.
What is the disease that causes loss of NKCC from the thick ascending limb? Barrters Syndrome
What is the effect on urine volume of blocking NKCC? Increase in urine volume
What is the name of the major sodium uptake protein in the apical membrane of collecting duct cells? The epithelial sodium channel (ENaC) Blocked by amiloride
Why does the chloride concentration of filtered fluid increase as it passes along the proximal tubule? It is reabsorbed at a slower rate than water. The concentration of most substances decreases except for Na+, which is reabsorbed isoosmotically with water.
Created by: IMC512
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